Natural resources and sustainable development laboratory, department of biology. Faculty of science, University Ibn Tofail, Kenitra, Morocco.
Biology and health laboratory, department of biology. Faculty of sciences, Ibn Tofail University, Kenitra, Morocco.
Tunis Med. 2024 May 5;102(5):289-295. doi: 10.62438/tunismed.v102i5.4825.
Tuberculosis, a global major concern, causes millions of deaths annually despite WHO strategies. A persistent gap in detection and treatment facilitates rapid spread in high-burden countries.
Analyze the clinical-epidemiological profile of tuberculosis patients in Laayoune and Tarfaya, Morocco, emphasizing risk factors and evolution of the tuberculosis Methods: Retrospective analysis of 1332 tuberculosis cases at the Respiratory Diseases Diagnosis and Treatment Center in Laayoune (2006-2012). Variables with P < 0.10 in univariate analysis were included in multivariate analysis using multiple logistic regression to define the risk factors for tuberculosis, expressed as odds ratios (OR) with a 95% confidence interval (CI).
The analysis revealed a pulmonary predominance (≈61%), with pleural (41.3%) and lymph node (31.5%) tuberculosis prevalent among extrapulmonary cases. Among 515 extrapulmonary tuberculosis cases, intestinal tuberculosis (14 cases) showed the highest mortality rate at 14.29%. The 15 to 64 age groups had a significantly higher risk of contracting pulmonary tuberculosis to children, and the 65 and over age group also had the highest risk of developing pulmonary tuberculosis (aOR=5.83 [2.43, 14.00]). Other risk factors included rural origin, personal history of tuberculosis, and smoking, all significantly associated with pulmonary tuberculosis (aOR=2.40 [1.001, 5.76]; aOR=2.00 [1.11, 3.61]; aOR=2.38 [1.40, 4.06]). Conversely, female gender was a protective factor (aOR=0.53 [0.40, 0.70]). Regarding recovery and loss to follow-up rates, they were higher in those with pulmonary tuberculosis (39.0% vs 2.1%; aOR=33.41 [17, 66.52]; 16.9% vs 10.3%; aOR=1.57 [1.02, 2.41], respectively).
Holistic initiatives across various sectors will be essential to eliminate tuberculosis by 2030.
尽管世界卫生组织制定了相关策略，但结核病仍是一个全球性的重大问题，每年仍有数百万人因此死亡。在高负担国家，检测和治疗方面的持续差距导致了结核病的快速传播。
分析摩洛哥拉尤恩和塔法亚呼吸疾病诊断和治疗中心的结核病患者的临床流行病学特征，重点关注危险因素和结核病的演变。
对 2006 年至 2012 年在拉尤恩呼吸疾病诊断和治疗中心的 1332 例结核病病例进行回顾性分析。单因素分析中 P＜0.10 的变量纳入多因素分析，采用多元逻辑回归定义结核病的危险因素，以比值比（OR）和 95%置信区间（CI）表示。
分析显示，肺结核占主导地位（约 61%），胸腔（41.3%）和淋巴结（31.5%）结核是肺外结核的主要类型。在 515 例肺外结核病例中，肠道结核（14 例）的死亡率最高，为 14.29%。15 至 64 岁年龄组与儿童相比，患肺结核的风险显著增加，65 岁及以上年龄组患肺结核的风险也最高（aOR=5.83[2.43，14.00]）。其他危险因素包括农村出身、个人结核病史和吸烟，这些因素与肺结核显著相关（aOR=2.40[1.001，5.76]；aOR=2.00[1.11，3.61]；aOR=2.38[1.40，4.06]）。相反，女性是保护因素（aOR=0.53[0.40，0.70]）。就恢复和失访率而言，肺结核患者的恢复和失访率较高（39.0%与 2.1%；aOR=33.41[17，66.52]；16.9%与 10.3%；aOR=1.57[1.02，2.41]）。
需要跨多个部门采取综合举措，才能在 2030 年消除结核病。
