Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, 273008, India.
Department of ENT, All India Institute of Medical Sciences, Gorakhpur, 273008, India.
Adv Exp Med Biol. 2024;1451:219-237. doi: 10.1007/978-3-031-57165-7_14.
The monkeypox virus (MPXV), responsible for human disease, has historically been limited to the African countries, with only a few isolated instances reported elsewhere in the world. Nevertheless, in recent years, there have been occurrences of monkeypox in regions where the disease is typically absent, which has garnered global interest. Within a period of less than four months, the incidence of MPXV infections has surged to over 48,000 cases, resulting in a total of 13 deaths. This chapter has addressed the genetics of the pox virus, specifically the human monkeypox virus, and its interaction with the immune systems of host organisms. The present chapter is skillfully constructed, encompassing diagnostic methodologies that span from traditional to developing molecular techniques. Furthermore, the chapter provides a succinct analysis of the therapeutic methods employed, potential future developments, and the various emerging difficulties encountered in illness management.
猴痘病毒（MPXV）可导致人类发病，历史上仅限于非洲国家，世界其他地方仅有少数孤立病例报告。然而，近年来，在通常没有这种疾病的地区也出现了猴痘，引起了全球关注。在不到四个月的时间里，猴痘病毒感染的发病率飙升至超过 48000 例，导致 13 人死亡。本章讨论了痘病毒的遗传学，特别是人类猴痘病毒及其与宿主生物体免疫系统的相互作用。这一章巧妙地构建，包括从传统到新兴分子技术的诊断方法。此外，本章还对所采用的治疗方法、潜在的未来发展以及疾病管理中遇到的各种新出现的困难进行了简洁的分析。
