State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, P.R. China.
Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, P.R. China.
Nat Prod Res. 2022 Jun;36(12):3085-3094. doi: 10.1080/14786419.2021.1958328. Epub 2021 Oct 25.
Three new biflavonoids, umcephabiovins C - E (), along with fourteen known compounds were isolated from the twigs and leaves of . Their structures and configurations were elucidated by UV, IR, NMR, ECD, and HR-ESI-MS spectra. Compounds exhibited significant -glucosidase inhibitory activity with IC values of 7.05 ± 2.66, 24.45 ± 4.73, and 1.84 ± 1.14 M, respectively. Compound showed moderate cytotoxicity against the BaF3/T315I cell line.
从枝叶中分离得到三个新的双黄酮类化合物 umcephabiovins C-E ()，并结合 14 个已知化合物。通过 UV、IR、NMR、ECD 和 HR-ESI-MS 光谱阐明了它们的结构和构型。化合物 表现出显著的 -葡萄糖苷酶抑制活性，IC 值分别为 7.05 ± 2.66、24.45 ± 4.73 和 1.84 ± 1.14 M。化合物 对 BaF3/T315I 细胞系表现出中等的细胞毒性。
