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急性护理环境中高血压的管理:美国心脏协会的科学声明。

The Management of Elevated Blood Pressure in the Acute Care Setting: A Scientific Statement From the American Heart Association.

出版信息

Hypertension. 2024 Aug;81(8):e94-e106. doi: 10.1161/HYP.0000000000000238. Epub 2024 May 28.

Abstract

Over the past 3 decades, a substantial body of high-quality evidence has guided the diagnosis and management of elevated blood pressure (BP) in the outpatient setting. In contrast, there is a lack of comparable evidence for guiding the management of elevated BP in the acute care setting, resulting in significant practice variation. Throughout this scientific statement, we use the terms acute care and inpatient to refer to care received in the emergency department and after admission to the hospital. Elevated inpatient BP is common and can manifest either as asymptomatic or with signs of new or worsening target-organ damage, a condition referred to as hypertensive emergency. Hypertensive emergency involves acute target-organ damage and should be treated swiftly, usually with intravenous antihypertensive medications, in a closely monitored setting. However, the risk-benefit ratio of initiating or intensifying antihypertensive medications for asymptomatic elevated inpatient BP is less clear. Despite this ambiguity, clinicians prescribe oral or intravenous antihypertensive medications in approximately one-third of cases of asymptomatic elevated inpatient BP. Recent observational studies have suggested potential harms associated with treating asymptomatic elevated inpatient BP, which brings current practice into question. Despite the ubiquity of elevated inpatient BPs, few position papers, guidelines, or consensus statements have focused on improving BP management in the acute care setting. Therefore, this scientific statement aims to synthesize the available evidence, provide suggestions for best practice based on the available evidence, identify evidence-based gaps in managing elevated inpatient BP (asymptomatic and hypertensive emergency), and highlight areas requiring further research.

摘要

在过去的 30 年中,大量高质量的证据为门诊环境中高血压(BP)的诊断和管理提供了指导。相比之下,在急性护理环境中,缺乏类似的证据来指导高血压的管理,导致实践差异很大。在本科学声明中,我们使用急性护理和住院来表示在急诊室和住院后接受的护理。住院期间血压升高很常见,可能表现为无症状,也可能出现新的或恶化的靶器官损伤迹象,这种情况称为高血压急症。高血压急症涉及急性靶器官损伤,应迅速治疗,通常使用静脉内降压药物,并在密切监测的环境下进行。然而,对于无症状的住院期间血压升高,开始或加强降压药物治疗的风险效益比不太明确。尽管存在这种不确定性,但临床医生仍在大约三分之一的无症状住院期间血压升高的情况下开具口服或静脉内降压药物。最近的观察性研究表明,治疗无症状的住院期间血压升高可能会带来潜在的危害,这对当前的实践提出了质疑。尽管住院期间血压升高很常见,但很少有专门针对改善急性护理环境中血压管理的立场文件、指南或共识声明。因此,本科学声明旨在综合现有证据,根据现有证据提供最佳实践建议,确定管理住院期间血压升高(无症状和高血压急症)方面的循证差距,并强调需要进一步研究的领域。

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