Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Assistance Publique-Hôpitaux de Paris, Hôpital Robert-Debré, Service d'Endocrinologie et Diabétologie, Paris, France.
J Endocrinol Invest. 2024 Dec;47(12):3129-3135. doi: 10.1007/s40618-024-02402-6. Epub 2024 May 28.
Active and Environmental Tobacco Smoke (ETS) are a global cause of death. Osteoporosis (Op) is the most common metabolic bone disorder worldwide, impacting on mortality and disability, with high health and welfare costs. Active smoking is a known risk factor for Op, but there is few information regarding Op and ETS in men.
The study aim is to evaluate the association between smoking habits and Op in community-dwelling men that have been subjected to Dual-X-ray Absorptiometry and completed a questionnaire about their own and cohabiter's smoking habits.
We performed a cross-sectional study based on administrative data. This study is part of the SIMON protocol. The binary logistic regression analysis was used to estimate the role of ETS on the risk of Op, adjusting for age, body mass index (BMI), type 2 diabetes mellitus (T2DM) and eGFR.
Four hundred sixteen men were selected and, based on questionnaire replies, 167 were classified as current smokers (CS), 93 as passive smokers (PS) and 156 as never smokers (NS). NS showed a lower prevalence of past fragility fracture, radiological features of osteoporosis and hypovitaminosis D compared to PS and CS (p < 0.05). NS showed a lower prevalence of Op compared to PS and CS, also after correction for age, BMI, T2DM and eGFR (p < 0.05).
The study results demonstrate that PS and CS have a higher risk of Op, fragility fractures and vitamin D deficiency compared to NS.
主动和环境烟草烟雾（ETS）是全球死亡的一个主要原因。骨质疏松症（Op）是全球最常见的代谢性骨病，对死亡率和残疾率有影响，且医疗保健费用高昂。主动吸烟是 Op 的已知危险因素，但关于男性 Op 和 ETS 的信息较少。
本研究旨在评估吸烟习惯与社区居住男性 Op 之间的关联，这些男性接受了双能 X 线吸收法（DXA）检查，并完成了一份关于自己和同居者吸烟习惯的问卷。
我们进行了一项基于行政数据的横断面研究。本研究是 SIMON 方案的一部分。采用二元逻辑回归分析来估计 ETS 对 Op 风险的作用，调整年龄、体重指数（BMI）、2 型糖尿病（T2DM）和 eGFR。
共选择了 416 名男性，根据问卷回答，167 名被归类为当前吸烟者（CS），93 名被归类为被动吸烟者（PS），156 名被归类为从不吸烟者（NS）。与 PS 和 CS 相比，NS 过去脆性骨折、骨质疏松症的影像学特征和维生素 D 缺乏症的发生率较低（p<0.05）。与 PS 和 CS 相比，NS 发生 Op 的风险也较低，即使在调整年龄、BMI、T2DM 和 eGFR 后也是如此（p<0.05）。
研究结果表明，与 NS 相比，PS 和 CS 发生 Op、脆性骨折和维生素 D 缺乏的风险更高。
