Aghaei Maryam, Kianpour Maryam, Mardanian Farahnaz, Farahbod Farnoosh, Fahami Fariba, Ghahremantermeh Mehdi
Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Nursing and Midwifery Care Research Center, Reproductive Sciences and Sexual Health Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Family Reprod Health. 2023 Dec;17(4):255-263. doi: 10.18502/jfrh.v17i4.14598.
In vitro and in vivo researches have shown that silver nanoparticles have more antimicrobial properties with a lower concentration than antifungal agents against candida vaginitis. Therefore, this study evaluated the therapeutic effect of silver nanoparticles (Nivasha spray15ppm) compared to clotrimazole 1% vaginal cream on candida vaginitis.
In this clinical trial study, 110 women with confirmed candida vaginitis randomly were divided into test (n=58) and control (n=52) groups. Silver nanoparticles spray with an applicator (Nivasha 15 ppm), and clotrimazole 1% were administered to test and control groups, respectively. Then, within ten days, post-intervention checkup and patient self-reported for treatment results were recorded in checklists and the data were analyzed statistically.
The improvement rate in test group (98.0%) was 1.44 times higher than in control (67.9%). Moreover, disease symptoms after the intervention (including unusual secretions, itching and burning, redness) in test group were significantly less than in the control, but there was no significant difference in the ratio of edema in two groups (p=0.071). Furthermore, the average recovery time (days) of all symptoms in test group was lower than control (p<0.05). Finally, the rate of patients' satisfaction with the treatment process in the test group (76.9%) was more than control (46.6%) (p=0.004).
Nivasha spray had more effectiveness compared to the clotrimazole 1%. Therefore, it can be used as an alternative drug in the treatment of Candida vaginitis.
体外和体内研究表明，与抗真菌剂相比，银纳米颗粒在较低浓度下对念珠菌性阴道炎具有更强的抗菌性能。因此，本研究评估了银纳米颗粒（尼瓦沙喷雾剂15ppm）与1%克霉唑阴道乳膏相比对念珠菌性阴道炎的治疗效果。
在这项临床试验研究中，110名确诊为念珠菌性阴道炎的女性被随机分为试验组（n = 58）和对照组（n = 52）。试验组和对照组分别使用带有涂抹器的银纳米颗粒喷雾剂（尼瓦沙15ppm）和1%克霉唑进行治疗。然后，在十天内，通过检查表记录干预后的检查情况和患者自我报告的治疗结果，并对数据进行统计分析。
试验组的改善率（98.0%）比对照组（67.9%）高1.44倍。此外，试验组干预后的疾病症状（包括异常分泌物、瘙痒和灼痛、发红）明显少于对照组，但两组的水肿比例无显著差异（p = 0.071）。此外，试验组所有症状的平均恢复时间（天）低于对照组（p < 0.05）。最后，试验组患者对治疗过程的满意度（76.9%）高于对照组（46.6%）（p = 0.004）。
与1%克霉唑相比，尼瓦沙喷雾剂疗效更佳。因此，它可作为治疗念珠菌性阴道炎的替代药物。
