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用于胰腺导管腺癌早期检测的影像学检查：实施筛查和监测计划中的更新和挑战。

Imaging for Early Detection of Pancreatic Ductal Adenocarcinoma: Updates and Challenges in the Implementation of Screening and Surveillance Programs.

机构信息

Department of Radiology, NYU Langone Health, 660 First Ave, 3rd Fl, New York, NY 10016.

Department of Radiology, Weill Cornell Medicine, New York, NY.

出版信息

AJR Am J Roentgenol. 2024 Aug;223(2):e2431151. doi: 10.2214/AJR.24.31151. Epub 2024 May 29.

DOI:10.2214/AJR.24.31151
PMID:38809122
Abstract

Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive cancers. It has a poor 5-year survival rate of 12%, partly because most cases are diagnosed at advanced stages, precluding curative surgical resection. Early-stage PDA has significantly better prognoses due to increased potential for curative interventions, making early detection of PDA critically important to improved patient outcomes. We examine current and evolving early detection concepts, screening strategies, diagnostic yields among high-risk individuals, controversies, and limitations of standard-of-care imaging.

摘要

胰腺导管腺癌 (PDA) 是最具侵袭性的癌症之一。其 5 年生存率仅为 12%，部分原因是大多数病例在晚期诊断，排除了根治性手术切除的可能性。由于更有可能进行根治性干预，早期 PDA 的预后明显更好，因此早期发现 PDA 对改善患者预后至关重要。我们检查了当前和不断发展的早期检测概念、筛查策略、高危人群的诊断收益、争议以及标准护理成像的局限性。

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Eur J Radiol. 2024 Apr;173:111374. doi: 10.1016/j.ejrad.2024.111374. Epub 2024 Feb 18.
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International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas.国际循证京都指南：胰腺导管内乳头状黏液性肿瘤的管理。
Pancreatology. 2024 Mar;24(2):255-270. doi: 10.1016/j.pan.2023.12.009. Epub 2023 Dec 28.
3
Assessing the robustness of a machine-learning model for early detection of pancreatic adenocarcinoma (PDA): evaluating resilience to variations in image acquisition and radiomics workflow using image perturbation methods.
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Abdom Radiol (NY). 2024 Mar;49(3):964-974. doi: 10.1007/s00261-023-04127-1. Epub 2024 Jan 4.
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