Reproductive Medicine Center, Suining Central Hospital, Suining, 629000, Sichuan, China.
Prenatal Diagnosis Center, Suining Central Hospital, Suining, 629000, Sichuan, China.
J Assist Reprod Genet. 2024 Aug;41(8):2137-2144. doi: 10.1007/s10815-024-03144-3. Epub 2024 May 29.
To examine the pattern of kisspeptin expression throughout the menstrual cycle in polycystic ovary syndrome (PCOS) patients under the ovulation induction and identify any possible associations with early pregnancy.
A prospective cohort of 80 PCOS women who expressed the desire for fertility was enrolled in this study. All of them received the ovulation induction by using letrozole. Levels of kisspeptin, luteinizing hormone (LH), and estradiol (E2) were measured at three different time points during menstruation. The early pregnancy rate was recorded for the study participants after three ovulation cycles.
Kisspeptin levels varied regularly during the menstrual cycle, reaching a peak on the day of hCG injection and decreasing after ovulation. There was no significant correlation between kisspeptin and LH levels. Basal kisspeptin levels decreased after letrozole treatment without a significant difference while LH and E2 levels decreased significantly. PCOS participants who became pregnant early had higher basal kisspeptin levels compared to non-pregnant PCOS patients, which had a significant difference (P = 0.006). And the average basal kisspeptin level in pregnant patients was 2293.0 ± 398.7 pg/ml, with a 95% confidence interval of 1511.5-3074.5 pg/ml.
Kisspeptin levels in PCOS women undergoing ovulation induction showed a regular variation, which was similar with the healthy women reported in previous studies. The use of LE may result in PCOS endocrine improvement and fertility achievement. In a certain range, kisspeptin might be a potential predictor for early pregnancy in PCOS patients as people with slightly higher basal kisspeptin levels seemed more likely to be pregnant.
研究多囊卵巢综合征（PCOS）患者在接受促排卵治疗过程中 kisspeptin 的表达模式，并探讨其与早期妊娠的关系。
前瞻性纳入 80 名有生育要求的 PCOS 患者，均采用来曲唑进行促排卵治疗。在月经周期的 3 个不同时间点检测 kisspeptin、促黄体生成素（LH）和雌二醇（E2）水平。研究对象在完成 3 个促排卵周期后记录早期妊娠率。
在月经周期中，kisspeptin 水平呈规律性变化，在 hCG 注射日达到峰值，排卵后下降。kisspeptin 水平与 LH 水平无显著相关性。与来曲唑治疗前相比，治疗后基础 kisspeptin 水平降低，但差异无统计学意义，而 LH 和 E2 水平显著降低。与未妊娠的 PCOS 患者相比，早期妊娠的 PCOS 患者基础 kisspeptin 水平更高，差异有统计学意义（P = 0.006）。妊娠患者的平均基础 kisspeptin 水平为 2293.0 ± 398.7 pg/ml，95%置信区间为 1511.5-3074.5 pg/ml。
接受促排卵治疗的 PCOS 患者的 kisspeptin 水平呈规律性变化，与既往研究报道的健康女性相似。LE 的应用可能导致 PCOS 内分泌改善和生育能力的获得。在一定范围内，kisspeptin 可能是 PCOS 患者早期妊娠的潜在预测指标，因为基础 kisspeptin 水平略高的患者妊娠的可能性更大。
