Tang Rong, Ding Xiaohong, Zhu Jianghu
Department of Pediatrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
The Second School of Medicine, Wenzhou Medical University, Wenzhou, China.
Front Endocrinol (Lausanne). 2019 May 10;10:298. doi: 10.3389/fendo.2019.00298. eCollection 2019.
Although the pathogenesis of Polycystic Ovary Syndrome (PCOS) is still unclear, the disturbance of hypothalamic-pituitary-gonadal (HPG) axis is suspected to be the main culprit in the development of PCOS. Kisspeptin, a hypothalamic peptide encoded by the KISS1 gene, is widely reported as a key factor in the regulation of luteinizing hormone (LH)/ follicular-stimulating hormone (FSH) secretion, which may be potentially involved with the development of PCOS. The objective of this study is to summarize the existing knowledge in the literature in terms of the circulating kisspeptin concentration in PCOS women, kisspeptin and metabolic profiles in PCOS women and kisspeptin expression in PCOS animal models. A systematic literature search was conducted using "Pubmed," "Embase," "Web of Science" for all English language articles published up to July 2018 with the terms "PCOS," "Stein-Leventhal Syndrome," "Polycystic ovary syndrome," "metastins" and "kisspeptin". Overall, kisspeptin levels are higher in the PCOS population, which supports the hypothesis that an over-active KISS1 system leads to enhanced HPG-axis activity, thereby causing irregular menstrual cycles and excessive androgen release in PCOS women.
尽管多囊卵巢综合征（PCOS）的发病机制仍不明确，但下丘脑-垂体-性腺（HPG）轴功能紊乱被怀疑是PCOS发病的主要原因。 kisspeptin是一种由KISS1基因编码的下丘脑肽，广泛报道其是调节黄体生成素（LH）/促卵泡激素（FSH）分泌的关键因子，这可能与PCOS的发病有关。 本研究的目的是总结现有文献中关于PCOS女性循环中kisspeptin浓度、PCOS女性kisspeptin与代谢特征以及PCOS动物模型中kisspeptin表达的知识。 使用“Pubmed”、“Embase”、“Web of Science”对截至2018年7月发表的所有英文文章进行系统文献检索，检索词为“PCOS”、“斯坦因-莱文塔尔综合征”、“多囊卵巢综合征”、“metastins”和“kisspeptin”。 总体而言，PCOS人群中kisspeptin水平较高，这支持了KISS1系统过度活跃导致HPG轴活性增强，从而引起PCOS女性月经周期不规律和雄激素过度释放的假说。
