Shea-Donohue T, Danquechin-Dorval E, Montcalm E, El-Bayar H, Durakovic A, Conklin J J, Dubois A
Gastroenterology. 1985 Mar;88(3):685-90. doi: 10.1016/0016-5085(85)90138-6.
The aim of the present study was to evaluate the effect of gamma-irradiation on soluble gastric mucus. Six conscious chair-adapted rhesus monkeys were studied once before and twice after exposure to ionizing irradiation (800 rads). Using a marker (99mTc-DTPA) dilution technique, acidic glycoprotein (AG), neutral glycoprotein (NG), ion, and fluid output were determined during a basal period and after the administration of an 80-ml water load. Irradiation significantly increased the outputs of both AG and NG during the basal period. After the water load, NG output remained elevated but irradiation abolished postload AG output thus inhibiting the normal rise in AG output stimulated by the load. Two days after irradiation NG output had returned to control levels whereas AG output was still suppressed. Sodium and potassium ion outputs were unaltered by irradiation. Chloride and fluid outputs were significantly inhibited on the day of irradiation but had returned to control levels within 3 days. These results indicate that irradiation produces significant changes in both the quantity and nature of the soluble mucus glycoproteins secreted into the gastric juice. It is suggested that these changes may compromise the protective ability of gastric mucus.
本研究的目的是评估γ射线辐射对可溶性胃黏液的影响。对6只适应坐在椅子上的清醒恒河猴在暴露于电离辐射（800拉德）之前进行了一次研究，并在暴露后进行了两次研究。使用标记物（99mTc-DTPA）稀释技术，在基础期和给予80毫升水负荷后，测定酸性糖蛋白（AG）、中性糖蛋白（NG）、离子和液体输出量。辐射显著增加了基础期AG和NG的输出量。水负荷后，NG输出量仍保持升高，但辐射消除了负荷后AG的输出量，从而抑制了负荷刺激引起的AG输出量的正常升高。辐射后两天，NG输出量已恢复到对照水平，而AG输出量仍受到抑制。辐射未改变钠和钾离子的输出量。辐射当天，氯离子和液体输出量显著受到抑制，但在3天内已恢复到对照水平。这些结果表明，辐射会使分泌到胃液中的可溶性黏液糖蛋白的数量和性质发生显著变化。有人认为，这些变化可能会损害胃黏液的保护能力。
