Chen Ling-Xiao, Yang Feng-Qing
Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, P. R. China.
J Sep Sci. 2024 Jun;47(11):e2400082. doi: 10.1002/jssc.202400082.
Sample preparation, including extraction, separation, and purification, is a vital process for natural product analysis. As an attractive sample pretreatment method, magnetic solid-phase extraction (MSPE) has gained plenty of attention, mainly due to its simpler operation, less consumption of organic solvents, and shorter processing time than traditional SPE. This updated review is devoted to summarizing the applications of MSPE based on different magnetic nanomaterials in the analysis of various natural products in complex matrixes, such as biological samples, plants, and Chinese herbal preparations in the past four years (2020-2023). The preparation and fabrication of different materials are briefly introduced. Furthermore, the extraction mechanism and interaction forces between adsorbent and analytes are elaborated, and the advantages and disadvantages of different adsorbents coupled with various analytical methods for MSPE of different natural products are summarized. Moreover, the future trends and opportunities for MSPE in the natural product analysis are discussed. It is expected that this work can provide updated information for future research on the applications of MSPE in such fields.
样品制备，包括提取、分离和纯化，是天然产物分析的关键过程。作为一种有吸引力的样品预处理方法，磁性固相萃取（MSPE）受到了广泛关注，主要是因为它操作更简单、有机溶剂消耗更少，且处理时间比传统固相萃取更短。这篇更新的综述致力于总结基于不同磁性纳米材料的磁性固相萃取在分析复杂基质（如生物样品、植物和中药制剂）中各种天然产物方面在过去四年（2020 - 2023年）的应用。简要介绍了不同材料的制备和制造方法。此外，阐述了吸附剂与分析物之间的萃取机理和相互作用力，并总结了不同吸附剂与用于不同天然产物磁性固相萃取的各种分析方法相结合的优缺点。此外，还讨论了磁性固相萃取在天然产物分析中的未来趋势和机遇。期望这项工作能为该领域未来关于磁性固相萃取应用的研究提供最新信息。
