Wicher V, Wicher K
Int Arch Allergy Appl Immunol. 1985;76(3):266-9. doi: 10.1159/000233703.
T lymphocytes were purified from peritoneal exudates from young male, inbred strain 2 guinea pigs infected with 8 X 10(7) Treponema pallidum Nichols and from control animals injected with normal rabbit testes extract. Groups of animals were sacrificed after 15, 30, 60, and 90 days of infection, and the cells were analyzed for their proliferative response to concanavalin A and phytohemagglutinin and to sonicated T. pallidum, Treponema phagedenis biotype Reiter, and normal rabbit testes extract. No significant differences were observed in the responses to mitogens. Cells from infected but not from control animals responded with significant proliferation to T. pallidum antigen, but neither infected nor control cells reacted to T. phagedenis Reiter antigen. Although cells from both infected and control animals responded to normal rabbit testes extract, this response in the infected animals was transient and much lower than the response to T. pallidum antigen.
从感染了8×10⁷ 梅毒螺旋体Nichols株的年轻雄性近交系2豚鼠的腹腔渗出液中以及从注射了正常兔睾丸提取物的对照动物中纯化T淋巴细胞。在感染后的15、30、60和90天处死动物组，分析细胞对刀豆球蛋白A、植物血凝素以及对超声处理的梅毒螺旋体、噬菌性密螺旋体生物型Reiter和正常兔睾丸提取物的增殖反应。在对有丝分裂原的反应中未观察到显著差异。来自感染动物而非对照动物的细胞对梅毒螺旋体抗原有显著增殖反应，但感染动物和对照动物的细胞对噬菌性密螺旋体Reiter抗原均无反应。尽管来自感染动物和对照动物的细胞对正常兔睾丸提取物均有反应，但感染动物中的这种反应是短暂的，且远低于对梅毒螺旋体抗原的反应。
