Baylie Temesgen, Tsega Wuhabie, Getinet Mamaru, Abebaw Desalegn, Azanaw Gashaw, Adugna Adane, Jemal Mohammed
Department of Biomedical Science, School of Medicine, Debre Markos University, Debre Markos, Ethiopia.
Department of Nursing, College of Health Science, Debre Markos University, Debre Markos, Ethiopia.
Metabol Open. 2024 May 20;22:100286. doi: 10.1016/j.metop.2024.100286. eCollection 2024 Jun.
The leaves of have been used traditionally for the management of diabetes mellitus. Thus, this study aimed to evaluate the Antioxidant and Antihyperglycemic Effects of leaves crude extract in streptozotocin-induced diabetic mice.
To Evaluate the Antihyperglycemic, and Antioxidant Effects of Dovyalis Abyssinica Leaves Extract in Streptozotocin-Induced Diabetic Mice. Male Swiss albino mice were induced into diabetes using 100 mg/kg of streptozotocin. Mice were allocated randomly into six groups, six mice per group. The body weight and FBG measurements were done on days 0, 7th, 14th and 21st of treatment. Additionally, in vitro Antioxidant Activity of the Extract was determined using a DPPH assay. The data were entered into Epi-Data version 4.6, exported to SPSS version 26.0, and analysed by using a one-way ANOVA followed by a Tukey post hoc test, and P < 0.05 was considered statistically significant.
Dovyalis Abyssinica leaves crude extract showed significant (P < 0.05-P< 0.001) blood-glucose-lowering activity. Moreover, the crude extract of reduced the fasting blood glucose level by 45.13 %, 52.51 %, 54.85 %, and 56.38 %, respectively, for DA 100, DA 200, DA 400, and GLC 5 mg/kg on the 21st day of treatment. After diabetic mice were treated with Dovyalis Abyssinica (100, 200, and 400 mg/kg) for 21 days, there was a significant increase in body weight as compared to diabetic control. Antioxidant activities of the leaf extract was found to be comparable to ascorbic acid with an IC50 of 140.04 μg/ml.
The present findings revealed that leaves could be useful for the management of diabetes mellitus and other abnormalities related to this metabolic disorder. Thus, the present study may support the traditional use of for diabetes mellitus treatment.
[植物名称]的叶子传统上用于治疗糖尿病。因此，本研究旨在评估[植物名称]叶粗提物对链脲佐菌素诱导的糖尿病小鼠的抗氧化和降血糖作用。
为评估阿比西尼亚刺李叶提取物对链脲佐菌素诱导的糖尿病小鼠的降血糖和抗氧化作用。雄性瑞士白化小鼠用100mg/kg链脲佐菌素诱导成糖尿病。小鼠随机分为六组，每组六只。在治疗的第0、7、14和21天测量体重和空腹血糖（FBG）。此外，使用DPPH法测定提取物的体外抗氧化活性。数据录入Epi-Data 4.6版，导出至SPSS 26.0版，采用单因素方差分析和Tukey事后检验进行分析，P<0.05被认为具有统计学意义。
阿比西尼亚刺李叶粗提物显示出显著的（P<0.05 - P<0.001）降血糖活性。此外，在治疗的第21天，DA 100、DA 200、DA 400和GLC 5mg/kg的粗提物分别使空腹血糖水平降低了45.13%、52.51%、54.85%和56.38%。糖尿病小鼠用阿比西尼亚刺李（100、200和400mg/kg）治疗21天后，与糖尿病对照组相比体重显著增加。发现叶提取物的抗氧化活性与抗坏血酸相当，IC50为140.04μg/ml。
目前的研究结果表明，[植物名称]叶可能对糖尿病及与这种代谢紊乱相关的其他异常情况的管理有用。因此，本研究可能支持[植物名称]在糖尿病治疗中的传统用途。
