Kifle Zemene Demelash, Belayneh Yaschilal Muche
Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Diabetes Metab Syndr Obes. 2020 Oct 29;13:4085-4094. doi: 10.2147/DMSO.S279475. eCollection 2020.
The leaves of (Rosaceae) have been used traditionally for the management of diabetes mellitus. Thus, this study aimed to evaluate the antidiabetic and anti-hyperlipidemic activity of leaves crude extract in streptozotocin-induced diabetic mice.
Antidiabetic and anti-hyperlipidemic activity of the crude extract of was studied in streptozotocin-induced diabetic mice. The effects of the extract on fasting blood glucose level, body weight, and serum lipid profiles were analyzed. One-way ANOVA followed by Tukey's post hoc test was used for data analysis and p<0.05 was considered as statistically significant.
Hagenia abyssinica leaves crude extract showed significant (p<0.05-p<0.001) blood-glucose-lowering activity. Moreover, the crude extract of reduced the fasting blood glucose level by 23.21%, 38.20%, 43.53%, and 58.99%, respectively, for CE100, CE 200, CE 400, and GLC 5 mg/kg on the 14th day of treatment. After diabetic mice were treated with (100, 200 and 400 mg/kg) for 14 days, there was a significant decrease in serum total cholesterol, very-low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and serum triglyceride and a significant increase in body weight, and HDL-cholesterol level as compared to diabetic control.
The present findings revealed that leaves could be useful for the management of diabetes mellitus and other abnormalities related to this metabolic disorder. Thus, the present study may support the traditional use of for diabetes mellitus treatment.
蔷薇科植物哈氏木兰的叶子在传统医学中一直被用于治疗糖尿病。因此，本研究旨在评估哈氏木兰叶粗提物对链脲佐菌素诱导的糖尿病小鼠的抗糖尿病和抗高脂血症活性。
在链脲佐菌素诱导的糖尿病小鼠中研究了哈氏木兰粗提物的抗糖尿病和抗高脂血症活性。分析了提取物对空腹血糖水平、体重和血清脂质谱的影响。采用单因素方差分析和Tukey事后检验进行数据分析，p<0.05被认为具有统计学意义。
哈氏木兰叶粗提物显示出显著的（p<0.05 - p<0.001）降血糖活性。此外，在治疗第14天时，CE100、CE200、CE400和GLC 5 mg/kg的哈氏木兰叶粗提物分别使空腹血糖水平降低了23.21%、38.20%、43.53%和58.99%。糖尿病小鼠用哈氏木兰（100、200和400 mg/kg）治疗14天后，与糖尿病对照组相比，血清总胆固醇、极低密度脂蛋白胆固醇、低密度脂蛋白胆固醇和血清甘油三酯显著降低，体重和高密度脂蛋白胆固醇水平显著升高。
本研究结果表明，哈氏木兰叶可用于治疗糖尿病及与这种代谢紊乱相关的其他异常情况。因此，本研究可能支持哈氏木兰在糖尿病治疗中的传统应用。
