Department of Community Health, College of Health and Medical Techniques, Al_FuratAl_Awsat Technical University, 31003 Al-Kufa, Iraq.
Department of Physiology and Pharmacology, College of Veterinary Medicine/University of Baghdad/Iraq.
Arch Razi Inst. 2023 Dec 30;78(6):1762-1770. doi: 10.32592/ARI.2023.78.6.1762. eCollection 2023 Dec.
Pentoxifylline (PTXF) is a vasoactive agent that plays a significant role in the treatment of thin-layer endometrium cases. The PTXF, also identified as oxpentifylline, is a member of xanthine derivatives and a competitive nonselective phosphodiesterase inhibitor leading to the elevation of intracellular cAMP, inhibition of tumor necrosis factor and leukotriene synthesis, activation of protein kinase A, and reduction of inflammation and innate immunity. Moreover, it is used as an agent to relieve muscle pain in people with peripheral artery disease (vascular irregularities). It is also an acceptable choice for the treatment of radiation-induced fibrosis. Therefore, the present study aimed to determine the advantageous impact of PTXF and PTXF-loaded poly lactic-co-glycolic acid (PLGA) on female rats after being exposed to ethanol to create a thin layer of the endometrium. For this purpose, 50 female rats were selected and divided into five groups (G1: negative normal control, G2: positive control, G3: PLGA only, G4: preference PTXF, and G5: PLGA-PTXF groups) for a 20-day treatment period. In this study, the histopathological section revealed a perfect improvement in the tissues of the uterine horn of female rats that induced endometria and were treated with PLGA-PTXF. In this group of rats, clear healing was achieved and there was an increase in the thickness of endometrium and myometrium, compared to the ordinary PTXF-treated group which had the lowest recovery characteristics. However, the positive control group underwent a significant decrease in terms of endometrium and myometrium thickness as well as vascular and glandular density. This study showed that the PTXF-loaded PLGA had the capacity to heal the thin layer of the endometrium by improving the levels of histopathological changes, especially regarding the thickness of the endometrium and myometrium more than the ordinary PTXF.
己酮可可碱（PTXF）是一种血管活性药物，在治疗薄型子宫内膜病例中发挥重要作用。PTXF 也被称为氧己酮，是黄嘌呤衍生物的一种，是一种竞争性非选择性磷酸二酯酶抑制剂，可导致细胞内 cAMP 升高、肿瘤坏死因子和白三烯合成抑制、蛋白激酶 A 激活以及炎症和先天免疫减少。此外，它被用作治疗周围动脉疾病（血管不规则）患者肌肉疼痛的药物。它也是治疗放射性纤维化的可接受选择。因此，本研究旨在确定 PTXF 及其负载于聚乳酸-共-羟基乙酸（PLGA）的药物对暴露于乙醇后形成薄型子宫内膜的雌性大鼠的有利影响。为此，选择了 50 只雌性大鼠，并将其分为五组（G1：阴性正常对照组，G2：阳性对照组，G3：PLGA 组，G4：PTXF 组，G5：PLGA-PTXF 组），进行为期 20 天的治疗。在这项研究中，组织学切片显示，用 PLGA-PTXF 处理诱导子宫内膜的雌性大鼠子宫角组织得到了完美改善。在该组大鼠中，实现了明确的愈合，并且子宫内膜和子宫肌层的厚度增加，与普通 PTXF 治疗组相比，后者的恢复特征最低。然而，阳性对照组的子宫内膜和子宫肌层厚度以及血管和腺体密度显著下降。本研究表明，负载 PTXF 的 PLGA 具有通过改善组织病理学变化水平来治愈薄型子宫内膜的能力，特别是在子宫内膜和子宫肌层的厚度方面，优于普通的 PTXF。
