Lathrop J C, Ree H J, McDuff H C
Obstet Gynecol. 1985 Mar;65(3 Suppl):91S-94S.
Patients who require construction of a neovagina provide an opportunity for researchers to study some of the possible factors that cause vaginal neoplasia. Intraepithelial neoplastic changes occurring in the neovagina, remote from the graft margins, cannot be attributed to preexisting disease in the vaginal site. Such changes are unlikely to represent an expression of the oncogenic potential of the transplanted tissue. The most likely cause of these changes is the presence of a local carcinogenic environmental factor. Two cases are presented to demonstrate and support this thesis. The treatment prescribed, local excision in one case and application of topical 5-fluorouracil in the other case, resulted in disease-free intervals in excess of eight years for both patients.
需要构建新阴道的患者为研究人员提供了一个机会，来研究一些可能导致阴道肿瘤形成的因素。在远离移植边缘的新阴道中发生的上皮内肿瘤性变化，不能归因于阴道部位先前存在的疾病。此类变化不太可能代表移植组织致癌潜能的一种表现。这些变化最可能的原因是存在局部致癌环境因素。现介绍两例病例以论证和支持这一论点。所采用的治疗方法，一例为局部切除，另一例为局部应用5-氟尿嘧啶，两名患者均实现了超过八年的无病期。
