Ballon S C, Roberts J A, Lagasse L D
Obstet Gynecol. 1979 Aug;54(2):163-6.
Twelve patients with vaginal intraepithelial neoplasia received topical therapy with 5% 5-fluorouracil cream. Six patients had carcinoma in situ, 5 had moderate dysplasia, and 1 had mild dysplasia. Five patients responded to 1 treatment course. Six patients required 2, and 1 patient required 3 courses of therapy to respond. Three patients developed recurrent vaginal intraepithelial neoplasia 11-16 months after therapy and were retreated with topical 5-fluorouracil. Vaginal irritation occurred in all patients but was limited to the duration of the treatment course.
12例阴道上皮内瘤变患者接受了5%氟尿嘧啶乳膏局部治疗。6例为原位癌，5例为中度发育异常，1例为轻度发育异常。5例患者对1个疗程的治疗有反应。6例患者需要2个疗程，1例患者需要3个疗程的治疗才有反应。3例患者在治疗后11 - 16个月出现复发性阴道上皮内瘤变，并再次接受氟尿嘧啶局部治疗。所有患者均出现阴道刺激症状，但仅限于治疗疗程期间。
