Caglar H, Hertzog R W, Hreshchyshyn M M
Obstet Gynecol. 1981 Nov;58(5):580-3.
In a prospective study, 27 patients with intraepithelial vaginal neoplasia diagnosed by colposcopically directed biopsies were treated with topical 5-fluorouracil. The cream was applied daily to the entire vagina until mucosal irritation occurred (5 to 10 days). Courses were repeated every 2 weeks for a total of 2 to 3 courses, which were considered 1 treatment, before response was evaluated. Those found to have persistent neoplasia as designated by positive vaginal cytology and/or colposcopically directed biopsies received a second 3-course treatment and were evaluated again. Except for 2 patients (1 who died from intercurrent disease during the treatment and another, evaluated prematurely after the first course of therapy, who was found to have persistent disease and was treated by other means), all patients responded with complete regression of vaginal intraepithelial neoplasia. Three patients developed reactivation of disease within 1 year, were retreated, and are currently completely free of disease. The authors believe the results of this study are very encouraging.
在一项前瞻性研究中，对27例经阴道镜引导活检诊断为阴道上皮内瘤变的患者采用局部5-氟尿嘧啶进行治疗。将乳膏每日涂抹于整个阴道，直至出现黏膜刺激（5至10天）。每2周重复一个疗程，共进行2至3个疗程，在评估疗效之前，这2至3个疗程被视为1次治疗。那些经阴道细胞学检查阳性和/或经阴道镜引导活检确诊为持续性瘤变的患者接受第二个3疗程治疗，并再次进行评估。除2例患者外（1例在治疗期间死于并发疾病，另一例在第一个疗程治疗后过早接受评估，被发现患有持续性疾病并采用其他方法治疗），所有患者的阴道上皮内瘤变均完全消退。3例患者在1年内疾病复发，接受再次治疗，目前疾病已完全消除。作者认为这项研究的结果非常令人鼓舞。
