Sillman F H, Boyce J G, Macasaet M A, Nicastri A D
Obstet Gynecol. 1981 Sep;58(3):356-60.
Sixteen patients with lower genital intraepithelial neoplasia were treated by 5-fluorouracil (5-FU)/chemosurgery: colposcopically directed excision of neoplastic epithelium pretreated with topical 5-FU. 5-FU loosens the neoplastic epithelium, facilitating its removal from the underlying stroma in a safe, minimally traumatic fashion. 5-FU/chemosurgery was undertaken in patients with vaginal neoplasia or those with lower genital neoplasia who were immunosuppressed or had a neoplastic syndrome, because conventional methods are often difficult or inadequate for these problems. In all 16 patients, the neoplasia went into remission. Two immunosuppressed patients developed recurrences of lesser dysplasia when 5-FU maintenance therapy was interrupted because of pregnancy. It was found that 5-FU/chemosurgery, followed by monthly 5-FU maintenance, may be the best treatment for intraepithelial neoplasia of the vagina or lower genital intraepithelial neoplasia in patients who are immunosuppressed or have a neoplastic syndrome.
16例下生殖道上皮内瘤变患者接受了5-氟尿嘧啶（5-FU）/化学外科治疗：在阴道镜引导下切除经局部5-FU预处理的肿瘤上皮。5-FU可使肿瘤上皮松解，便于以安全、微创的方式从其下方的基质中切除。5-FU/化学外科治疗适用于患有阴道肿瘤或患有下生殖道肿瘤且免疫抑制或患有肿瘤综合征的患者，因为传统方法对于这些问题往往困难或不足。在所有16例患者中，肿瘤均缓解。2例免疫抑制患者在因妊娠中断5-FU维持治疗时出现较轻发育异常的复发。研究发现，对于免疫抑制或患有肿瘤综合征的患者，5-FU/化学外科治疗后每月进行5-FU维持治疗可能是阴道上皮内瘤变或下生殖道上皮内瘤变的最佳治疗方法。
