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结直肠癌:正确把握视角与背景。

Colorectal cancer: Getting the perspective and context right.

作者信息

Lu Jun De, Tan Kok Yang

机构信息

Department of General Surgery, Khoo Teck Puat Hospital, Singapore 768828, Singapore.

Department of Surgery, Khoo Teck Puat Hospital, Singapore 768828, Singapore.

出版信息

World J Clin Oncol. 2024 May 24;15(5):599-602. doi: 10.5306/wjco.v15.i5.599.

Abstract

Colorectal cancer (CRC) is a significant global health burden, being the third leading cancer globally. Its incidence has been observed to be higher in developed regions such as North America and Europe with geographical variations in mortality rates. Efforts to address this disease burden include promoting early detection through screening and implementing treatment strategies to improve patient outcomes. With the growing and aging population, the incidence of CRC will undoubtedly increase. These epidemiological trends will mean that healthcare professionals will increasingly encounter CRC in more complex patients. Hence, it becomes imperative to have a deeper appreciation of the pathophysiology of CRC and understand the intricate interplay between a patient's physiology and their goals of care before offering treatment. This review article will aim to encapsulate the important nuances and perspectives of managing this disease in the context of an elderly patient.

摘要

结直肠癌(CRC)是一项重大的全球健康负担,是全球第三大主要癌症。据观察,其发病率在北美和欧洲等发达地区较高,死亡率存在地域差异。应对这一疾病负担的努力包括通过筛查促进早期发现,并实施治疗策略以改善患者预后。随着人口的增长和老龄化,CRC的发病率无疑将会上升。这些流行病学趋势意味着医疗保健专业人员将在越来越复杂的患者中越来越多地遇到CRC。因此,在提供治疗之前深入了解CRC的病理生理学,并理解患者生理状况与其护理目标之间的复杂相互作用变得至关重要了。这篇综述文章旨在概括在老年患者背景下管理这一疾病的重要细微差别和观点。

相似文献

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Colorectal cancer: Getting the perspective and context right.结直肠癌:正确把握视角与背景。
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Managing elderly with colorectal cancer.管理老年结直肠癌患者。
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本文引用的文献

1
Colon and rectal cancer: An emergent public health problem.结直肠癌:一个亟待解决的公共卫生问题。
World J Gastroenterol. 2024 Feb 21;30(7):644-651. doi: 10.3748/wjg.v30.i7.644.
2
Colorectal cancer statistics, 2023.2023 年结直肠癌统计数据。
CA Cancer J Clin. 2023 May-Jun;73(3):233-254. doi: 10.3322/caac.21772. Epub 2023 Mar 1.
4
Increasing Incidence Rates of Colorectal Cancer at Ages 50-54 Years.50至54岁人群中结直肠癌发病率不断上升。
Gastroenterology. 2022 Mar;162(3):964-965.e3. doi: 10.1053/j.gastro.2021.10.039. Epub 2021 Oct 29.
8
Signaling pathways involved in colorectal cancer progression.参与结直肠癌进展的信号通路。
Cell Biosci. 2019 Dec 2;9:97. doi: 10.1186/s13578-019-0361-4. eCollection 2019.

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