Ellis J A, DeMartini J C
Vet Pathol. 1985 Jan;22(1):32-41. doi: 10.1177/030098588502200105.
Morphologic, immunohistochemical, and morphometric studies were conducted on the posterior mediastinal lymph nodes of eleven sheep with naturally occurring ovine progressive pneumonia and four apparently healthy sheep with no pulmonary lesions (three seropositive, one seronegative for antibody to ovine progressive pneumonia virus). Compared with lesion-free sheep, sheep with ovine progressive pneumonia had a seven-fold increase in B lymphocyte areas and a 21/2-fold increase in T lymphocyte areas of these lymph nodes. Immunochemistry revealed cytoplasmic immunoglobulin G in scattered cells of germinal centers, medullary cords and interfollicular areas and membrane-associated immunoglobulin G in dendritic cells of germinal centers. Immunoglobulin M staining cells were widely scattered in germinal centers and medullary cords. Although B cell hyperplasia seemed to be the predominant process in lymph nodes of sheep with ovine progressive pneumonia, this was not accompanied by the expected degree of plasmacytosis, morphologically and immunohistochemically. These findings may represent an aberrancy of immunoregulation in ovine progressive pneumonia.
对11只自然发生绵羊进行性肺炎的绵羊和4只无肺部病变的明显健康绵羊（3只血清阳性，1只绵羊进行性肺炎病毒抗体血清阴性）的后纵隔淋巴结进行了形态学、免疫组织化学和形态计量学研究。与无病变绵羊相比，患有绵羊进行性肺炎的绵羊这些淋巴结的B淋巴细胞区域增加了7倍，T淋巴细胞区域增加了2.5倍。免疫化学显示生发中心、髓索和滤泡间区域的散在细胞中有细胞质免疫球蛋白G，生发中心的树突状细胞中有膜相关免疫球蛋白G。免疫球蛋白M染色细胞广泛分布于生发中心和髓索。虽然B细胞增生似乎是患有绵羊进行性肺炎的绵羊淋巴结中的主要过程，但在形态学和免疫组织化学上，这并未伴随着预期程度的浆细胞增多。这些发现可能代表了绵羊进行性肺炎中免疫调节的异常。
