Lairmore M D, Akita G Y, Russell H I, DeMartini J C
Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
J Virol. 1987 Dec;61(12):4038-42. doi: 10.1128/JVI.61.12.4038-4042.1987.
Ruminant lentiviruses share genomic sequences and biologic properties with human immunodeficiency viruses. Four ovine lentivirus strains were assessed for cytopathic effects and virus replication. Lentivirus isolate H/24 produced high virus titers and lysis of synovial cells but replicated slowly and caused no fusion of alveolar macrophages. Lentivirus isolates 84/28 and 85/14 produced low virus titers, less syncytia, and limited or no cell lysis in synovial cells and macrophages. In contrast, ovine lentivirus isolate 85/34 produced early peak virus titers and caused rapid fusion and lysis of both macrophages and synovial cells. Ovine lentivirus isolates which were cytopathic for macrophages induced lymphoproliferative disease when inoculated into lambs.
反刍动物慢病毒与人类免疫缺陷病毒具有共同的基因组序列和生物学特性。对四株绵羊慢病毒毒株进行了细胞病变效应和病毒复制评估。慢病毒分离株H/24产生高病毒滴度并导致滑膜细胞裂解，但复制缓慢且未引起肺泡巨噬细胞融合。慢病毒分离株84/28和85/14产生低病毒滴度，较少的多核巨细胞，并且在滑膜细胞和巨噬细胞中细胞裂解有限或无细胞裂解。相比之下，绵羊慢病毒分离株85/34产生早期病毒滴度峰值，并导致巨噬细胞和滑膜细胞迅速融合和裂解。对巨噬细胞具有细胞病变作用的绵羊慢病毒分离株接种到羔羊体内时可诱发淋巴细胞增生性疾病。
