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较高的 1,3-丁二烯暴露与更严重的听力损失有关。

Higher exposure to 1,3-butadiene is associated with more severe hearing loss.

机构信息

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, 101 Daehak-Ro, Jongno-gu, Seoul, Republic of Korea.

出版信息

Sci Rep. 2024 Jun 5;14(1):12899. doi: 10.1038/s41598-024-63757-7.

DOI:10.1038/s41598-024-63757-7
PMID:38839853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11153631/
Abstract

While volatile organic compounds (VOCs) impair various organs, their influence on hearing loss (HL) has not been extensively researched. We aimed to identify the association between VOCs and HL or high-frequency hearing loss (HFHL). We extracted data on age, sex, pure tone audiometry, hypertension, occupational noise exposure, and creatinine-corrected urine VOC metabolite concentrations from the eighth Korea National Health and Nutrition Survey. Among the VOC metabolites, N-acetyl-S-(benzyl)-L-cysteine (BMA, P = 0.004), N-acetyl-S-(phenyl)-L-cysteine (SPMA, P = 0.027), and N-acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (DHBMA, P < 0.001) showed associations with HL. Additionally, HFHL exhibited significant associations with BMA (P = 0.005), 3- and 4-methylhippuric acid (3, 4 MHA, P = 0.049), mandelic acid (MA, P = 0.015), SPMA (P < 0.001), N-acetyl-S-(3-hydroxypropyl)-L-cysteine (3-HPMA, P < 0.001), and DHBMA (P < 0.001). After controlling other factors, DHBMA were associated with HL (P = 0.021) and HFHL (P = 0.014) and exhibited a linear association with the mean hearing level (β = 0.054, P = 0.024) and high-frequency hearing level (β = 0.045, P = 0.037). Since 1,3-butadiene may act as an ototoxic material, early screening for workers exposed to 1,3-butadiene and reducing exposure to 1,3-butadiene in everyday life may be helpful to prevent further HL.

摘要

虽然挥发性有机化合物 (VOCs) 会损害各种器官，但它们对听力损失 (HL) 的影响尚未得到广泛研究。我们旨在确定 VOC 与 HL 或高频听力损失 (HFHL) 之间的关联。我们从第八次韩国国家健康和营养调查中提取了年龄、性别、纯音测听、高血压、职业噪声暴露以及肌酐校正尿液 VOC 代谢物浓度的数据。在 VOC 代谢物中，N-乙酰-S-(苄基)-L-半胱氨酸 (BMA，P=0.004)、N-乙酰-S-(苯基)-L-半胱氨酸 (SPMA，P=0.027) 和 N-乙酰-S-(3,4-二羟基丁基)-L-半胱氨酸 (DHBMA，P<0.001) 与 HL 相关。此外，HFHL 与 BMA (P=0.005)、3- 和 4-甲基马尿酸 (3,4 MHA，P=0.049)、扁桃酸 (MA，P=0.015)、SPMA (P<0.001)、N-乙酰-S-(3-羟基丙基)-L-半胱氨酸 (3-HPMA，P<0.001) 和 DHBMA (P<0.001) 呈显著相关。在控制其他因素后，DHBMA 与 HL (P=0.021) 和 HFHL (P=0.014) 相关，并与平均听力水平 (β=0.054，P=0.024) 和高频听力水平 (β=0.045，P=0.037) 呈线性相关。由于 1,3-丁二烯可能是一种耳毒性物质，因此对接触 1,3-丁二烯的工人进行早期筛查，并减少日常生活中接触 1,3-丁二烯，可能有助于预防进一步的 HL。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ce5/11153631/bbfe382cea1b/41598_2024_63757_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ce5/11153631/7e1c8e2c3559/41598_2024_63757_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ce5/11153631/fa0592386142/41598_2024_63757_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ce5/11153631/bbfe382cea1b/41598_2024_63757_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ce5/11153631/7e1c8e2c3559/41598_2024_63757_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ce5/11153631/fa0592386142/41598_2024_63757_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ce5/11153631/bbfe382cea1b/41598_2024_63757_Fig3_HTML.jpg

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本文引用的文献

1
Environmental pollutants and their effects on human health.环境污染物及其对人类健康的影响。
Heliyon. 2023 Aug 25;9(9):e19496. doi: 10.1016/j.heliyon.2023.e19496. eCollection 2023 Sep.
2
Noise-Induced Hearing Loss.噪声性听力损失
J Clin Med. 2023 Mar 17;12(6):2347. doi: 10.3390/jcm12062347.
3
Probabilistic human health risk assessment of 1,3-butadiene and styrene exposure using Monte Carlo simulation technique in the carpet production industry.采用蒙特卡罗模拟技术对地毯生产行业中 1,3-丁二烯和苯乙烯暴露的概率性人体健康风险评估。
Sci Rep. 2022 Dec 21;12(1):22103. doi: 10.1038/s41598-022-26537-9.
4
Exploring the association of organochlorine pesticides exposure and hearing impairment in United States adults.探讨美国成年人有机氯农药暴露与听力损伤的关联。
Sci Rep. 2022 Jul 13;12(1):11887. doi: 10.1038/s41598-022-15892-2.
5
The Risk of Hearing Impairment From Ambient Air Pollution and the Moderating Effect of a Healthy Diet: Findings From the United Kingdom Biobank.环境空气污染导致听力受损的风险及健康饮食的调节作用：来自英国生物银行的研究结果
Front Cell Neurosci. 2022 Apr 6;16:856124. doi: 10.3389/fncel.2022.856124. eCollection 2022.
6
Long-term exposure to ambient air pollutants and hearing loss in Korean adults.韩国成年人长期暴露于环境空气污染物与听力损失
Sci Total Environ. 2022 May 10;820:153124. doi: 10.1016/j.scitotenv.2022.153124. Epub 2022 Jan 17.
7
1,3-Butadiene: a ubiquitous environmental mutagen and its associations with diseases.1,3 - 丁二烯：一种普遍存在的环境诱变剂及其与疾病的关联。
Genes Environ. 2022 Jan 10;44(1):3. doi: 10.1186/s41021-021-00233-y.
8
Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction.接触挥发性有机化合物——丙烯醛、1,3-丁二烯和巴豆醛——与血管功能障碍有关。
Environ Res. 2021 May;196:110903. doi: 10.1016/j.envres.2021.110903. Epub 2021 Feb 24.
9
Environmental exposure to lead and cadmium and hearing loss in Chinese adults: A case-control study.环境铅镉暴露与中国成年人听力损失的病例对照研究。
PLoS One. 2020 May 20;15(5):e0233165. doi: 10.1371/journal.pone.0233165. eCollection 2020.
10
The association between urinary levels of 1,3-butadiene metabolites, cardiovascular risk factors, microparticles, and oxidative stress products in adolescents and young adults.青少年和青年中1,3 - 丁二烯代谢物的尿液水平、心血管危险因素、微粒与氧化应激产物之间的关联。
J Hazard Mater. 2020 Sep 5;396:122745. doi: 10.1016/j.jhazmat.2020.122745. Epub 2020 Apr 20.