Yuan Lanlai, Li Dankang, Tian Yaohua, Sun Yu
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Cell Neurosci. 2022 Apr 6;16:856124. doi: 10.3389/fncel.2022.856124. eCollection 2022.
The link between hearing impairment and air pollution has not been established, and the moderating effect of a healthy diet has never been investigated before. The purpose of this study was to investigate the association between air pollution and hearing impairment in British adults aged 37-73 years, and whether the association was modified by a healthy diet. We performed a cross-sectional population-based study with 158,811 participants who provided data from United Kingdom Biobank. A multivariate logistic regression model was used to investigate the link between air pollution and hearing impairment. Subgroup and effect modification analyses were carried out according to healthy diet scores, gender, and age. In the fully adjusted model, we found that exposure to PM, NO, and NO was associated with hearing impairment [PM: odds ratio (OR) = 1.15, 95% confidence interval (95% CI) 1.02-1.30, = 0.023; NO: OR = 1.02, 95% CI 1.00-1.03, = 0.040; NO: OR = 1.03, 95% CI 1.01-1.06, = 0.044], while PM and PM absorbance did not show similar associations. We discovered an interactive effect of age and air pollution on hearing impairment, but a healthy diet did not. The findings suggested that exposure to PM, NO and NO was linked to hearing impairment in British adults, whereas PM and PM absorbance did not show similar associations. These may help researchers focus more on the impact of air pollution on hearing impairment and provide a basis for developing effective prevention strategies.
听力障碍与空气污染之间的联系尚未确立，健康饮食的调节作用此前也从未被研究过。本研究的目的是调查英国37至73岁成年人中空气污染与听力障碍之间的关联，以及这种关联是否会因健康饮食而改变。我们对来自英国生物银行的158,811名参与者进行了一项基于人群的横断面研究。使用多元逻辑回归模型来研究空气污染与听力障碍之间的联系。根据健康饮食得分、性别和年龄进行亚组分析和效应修饰分析。在完全调整模型中，我们发现暴露于细颗粒物（PM）、一氧化氮（NO）和二氧化氮（NO₂）与听力障碍相关[PM：比值比（OR）= 1.15，95%置信区间（95%CI）1.02 - 1.30，P = 0.023；NO：OR = 1.02，95%CI 1.00 - 1.03，P = 0.040；NO₂：OR = 1.03，95%CI 1.01 - 1.06，P = 0.044]，而PM和PM吸光度未显示出类似关联。我们发现年龄和空气污染对听力障碍存在交互作用，但健康饮食没有。研究结果表明，在英国成年人中，暴露于PM、NO和NO₂与听力障碍有关，而PM和PM吸光度未显示出类似关联。这些可能有助于研究人员更多地关注空气污染对听力障碍的影响，并为制定有效的预防策略提供依据。
