合成胰岛素样生长因子II
Synthetic insulin-like growth factor II.
作者信息
Li C H, Yamashiro D, Hammonds R G, Westphal M
出版信息
Biochem Biophys Res Commun. 1985 Mar 15;127(2):420-4. doi: 10.1016/s0006-291x(85)80177-7.
PMID:3884009
Abstract
Human insulin-like growth factor II with 67 amino acid residues and three disulfide bridges has been synthesized by the solid-phase method. Homogeneity of the synthetic product is ascertained by chromatofocusing, high performance liquid chromatography and amino acid analysis. In both radioimmunoassay and radioreceptor assay, the synthetic product is indistinguishable from the natural hormone.
摘要
具有67个氨基酸残基和三个二硫键的人胰岛素样生长因子II已通过固相法合成。合成产物的同质性通过色谱聚焦、高效液相色谱和氨基酸分析来确定。在放射免疫测定和放射受体测定中，合成产物与天然激素无法区分。
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