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使用多巴胺修饰的透明质酸和苯硼酸修饰的壳聚糖制备多功能水凝胶敷料及其特性

Fabrication and characteristics of multifunctional hydrogel dressings using dopamine modified hyaluronic acid and phenylboronic acid modified chitosan.

作者信息

Han Yanting, Cao Jing, Li Man, Ding Peng, Yang Yujie, Okoro Oseweuba Valentine, Sun Yanfang, Jiang Guohua, Shavandi Amin, Nie Lei

机构信息

College of Life Sciences, Xinyang Normal University, Xinyang, China.

Université libre de Bruxelles (ULB), École polytechnique de Bruxelles-3BIO-BioMatter, Brussels, Belgium.

出版信息

Front Chem. 2024 May 22;12:1402870. doi: 10.3389/fchem.2024.1402870. eCollection 2024.

DOI:10.3389/fchem.2024.1402870
PMID:38841337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11150582/
Abstract

The healing of damaged skin is a complex and dynamic process, and the multi-functional hydrogel dressings could promote skin tissue healing. This study, therefore, explored the development of a composite multifunctional hydrogel (HDCP) by incorporating the dopamine modified hyaluronic acid (HA-DA) and phenylboronic acid modified chitosan (CS-PBA) crosslinked using boric acid ester bonds. The integration of HA-DA and CS-PBA could be confirmed using the Fourier transform infrared spectrometer and H nuclear magnetic resonance analyses. The fabricated HDCP hydrogels exhibited porous structure, elastic solid behavior, shear-thinning, and adhesion properties. Furthermore, the HDCP hydrogels exhibited antibacterial efficacy against Gram-negative () and Gram-positive (). Subsequently, the cytocompatibility of the HDCP hydrogels was verified through CCK-8 assay and fluorescent image analysis following co-cultivation with NIH-3T3 cells. This research presents an innovative multifunctional hydrogel that holds promise as a wound dressing for various applications within the realm of wound healing.

摘要

受损皮肤的愈合是一个复杂且动态的过程，多功能水凝胶敷料可以促进皮肤组织愈合。因此，本研究通过将多巴胺修饰的透明质酸（HA-DA）和苯硼酸修饰的壳聚糖（CS-PBA）结合，利用硼酸酯键交联，探索了一种复合多功能水凝胶（HDCP）的开发。HA-DA和CS-PBA的结合可以通过傅里叶变换红外光谱仪和氢核磁共振分析得到证实。制备的HDCP水凝胶具有多孔结构、弹性固体行为、剪切变稀和粘附性能。此外，HDCP水凝胶对革兰氏阴性菌（）和革兰氏阳性菌（）具有抗菌功效。随后，通过CCK-8测定和与NIH-3T3细胞共培养后的荧光图像分析，验证了HDCP水凝胶的细胞相容性。本研究提出了一种创新的多功能水凝胶，有望作为一种伤口敷料用于伤口愈合领域的各种应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/f2f757e51eed/fchem-12-1402870-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/424b97012b4f/FCHEM_fchem-2024-1402870_wc_sch1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/03b305e63f11/fchem-12-1402870-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/ddee682a5cb1/fchem-12-1402870-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/6d6a301f6896/fchem-12-1402870-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/86cffc9b06d8/fchem-12-1402870-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/2bedc032bb7c/fchem-12-1402870-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/3464abe9933d/fchem-12-1402870-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/f2f757e51eed/fchem-12-1402870-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/424b97012b4f/FCHEM_fchem-2024-1402870_wc_sch1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/03b305e63f11/fchem-12-1402870-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/ddee682a5cb1/fchem-12-1402870-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/6d6a301f6896/fchem-12-1402870-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/86cffc9b06d8/fchem-12-1402870-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/2bedc032bb7c/fchem-12-1402870-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/3464abe9933d/fchem-12-1402870-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d92/11150582/f2f757e51eed/fchem-12-1402870-g007.jpg

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本文引用的文献

[1]
Facile preparation of self-healing hydrogels based on chitosan and PVA with the incorporation of curcumin-loaded micelles for wound dressings.

Biomed Mater. 2024-1-25

[2]
Studies on Agrochemical Controlled Release Behavior of Copolymer Hydrogel with PVA Blends of Natural Polymers and Their Water-Retention Capabilities in Agricultural Soil.

Polymers (Basel). 2023-8-25

[3]
Injectable, self-healing, transparent, and antibacterial hydrogels based on chitosan and dextran for wound dressings.

Int J Biol Macromol. 2023-4-1

[4]
Hyaluronic acid skin penetration evaluated by tape stripping using ELISA kit assay.

J Pharm Biomed Anal. 2023-2-5

[5]
Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy.

J Nanobiotechnology. 2022-10-1

[6]
Chitosan@Puerarin hydrogel for accelerated wound healing in diabetic subjects by miR-29ab1 mediated inflammatory axis suppression.

Bioact Mater. 2022-5-11

[7]
Temperature, pH, and Glucose Responsive Gels via Simple Mixing of Boroxole- and Glyco-Based Polymers.

ACS Macro Lett. 2013-3-19

[8]
Injectable multifunctional CMC/HA-DA hydrogel for repairing skin injury.

Mater Today Bio. 2022-4-9

[9]
Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing.

Bioact Mater. 2022-3-9

[10]
An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing.

Bioact Mater. 2022-3-10

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