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丹参提取物：一种有前途的抗特应性皮炎活性物质来源。

Salvia miltiorrhiza bunge extracts: a promising source for anti-atopic dermatitis activity.

机构信息

Smart Farm Research Center, Korea Institute of Science and Technology (KIST), Gangneung, Gangwon, 25451, Republic of Korea.

Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Daejeon, 34113, Republic of Korea.

出版信息

BMC Complement Med Ther. 2024 Jun 6;24(1):217. doi: 10.1186/s12906-024-04524-z.

DOI:10.1186/s12906-024-04524-z
PMID:38844985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11155122/
Abstract

BACKGROUND

Atopic dermatitis (AD) is a chronic inflammatory condition characterized by the accumulation of reactive oxygen species and the expression of inflammatory factors. Regarding its anti-atopic activity, numerous traditional medicinal materials and secondary metabolic products play pivotal roles in modulating the associated mechanisms.

METHODS

This study aimed to utilize Salvia miltiorrhiza Bunge (SMB) as an anti-AD source. In-vitro activity assessments and qualitative and quantitative analyses using UPLC-TQ-MS/MS and HPLC-DAD were conducted in two cultivars ('Dasan' and 'Kosan'). Statistical analysis indicated that the profiles of their secondary metabolites contribute significantly to their pharmacological properties. Consequently, bio-guided fractionation was undertaken to figure out the distinct roles of the secondary metabolites present in SMB.

RESULTS

Comparative study of two cultivars indicated that 'Dasan', having higher salvianolic acid A and B, exhibited stronger antioxidant and anti-inflammatory activities. Meanwhile, 'Kosan', containing higher tanshinones, showed higher alleviating activities on anti-AD related genes in mRNA levels. Additionally, performed bio-guided fractionation re-confirmed that the hydrophilic compounds of SMB can prevent AD by inhibiting accumulation of ROS and suppressing inflammatory factors and the lipophilic components can directly inhibit AD.

CONCLUSIONS

SMB was revealed as a good source for anti-AD activity. Several bioactive compounds were identified from the UPLC-TQ-MS/MS and different compounds content was linked to biological activities. Characterization of these compounds may be helpful to understand differential role of secondary metabolites from SMB on alleviation of AD.

摘要

背景

特应性皮炎（AD）是一种慢性炎症性疾病，其特征在于活性氧物质的积累和炎症因子的表达。关于其抗特应性活性，许多传统药用植物和次生代谢产物在调节相关机制方面发挥着关键作用。

方法

本研究旨在利用丹参（SMB）作为抗 AD 的来源。采用 UPLC-TQ-MS/MS 和 HPLC-DAD 进行了两种栽培品种（“Dasan”和“Kosan”）的体外活性评估以及定性和定量分析。统计分析表明，它们的次生代谢物谱对其药理特性有重要贡献。因此，进行了生物导向的馏分分离，以确定 SMB 中存在的次生代谢物的不同作用。

结果

两种栽培品种的比较研究表明，含有较高的丹参酸 A 和 B 的“Dasan”表现出更强的抗氧化和抗炎活性。同时，含有较高丹参酮的“Kosan”在 mRNA 水平上对抗 AD 相关基因表现出更高的缓解活性。此外，进行的生物导向馏分分离再次证实，SMB 的亲水性化合物可以通过抑制 ROS 的积累和抑制炎症因子来预防 AD，而亲脂性成分可以直接抑制 AD。

结论

SMB 被揭示为一种具有抗 AD 活性的良好来源。从 UPLC-TQ-MS/MS 中鉴定出了几种生物活性化合物，不同化合物的含量与生物活性有关。这些化合物的特征描述可能有助于理解 SMB 次生代谢物对 AD 缓解的不同作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/ab2513715297/12906_2024_4524_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/6652c92fd7fc/12906_2024_4524_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/3d900de95cba/12906_2024_4524_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/b7710ea8016c/12906_2024_4524_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/def414232b4a/12906_2024_4524_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/20cb42e9ec8a/12906_2024_4524_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/dc3ffc50379c/12906_2024_4524_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/ab2513715297/12906_2024_4524_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/6652c92fd7fc/12906_2024_4524_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/3d900de95cba/12906_2024_4524_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/b7710ea8016c/12906_2024_4524_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/def414232b4a/12906_2024_4524_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/20cb42e9ec8a/12906_2024_4524_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/dc3ffc50379c/12906_2024_4524_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fa2/11155122/ab2513715297/12906_2024_4524_Fig8_HTML.jpg

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