Farooq Saba, Ngaini Zainab
Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300, Kota Samarahan, Sarawak, Malaysia.
Department of Basic and Applied Chemistry, Faculty of Science and Technology, University of Central Punjab, 54000, Lahore, Pakistan.
Curr Top Med Chem. 2025;25(1):47-62. doi: 10.2174/0115680266303704240524080333.
Flavonoids belong to the polyphenol group that naturally exists in fruits, vegetables, tea, and grains. Flavonoids, as secondary metabolites, show indispensable contributions to biological processes and the responses of plants to numerous environmental factors. The bioactivity of flavonoids depends on C6-C3-C6 ring substitution patterns that exhibit bioactive antioxidant, antimicrobial, antifungal, antitumor, and anti-inflammatory properties. The synthesis of flavonoids has been reported by various methodologies. Therefore, the present review systematically summarizes the synthesis of recent heterocyclic flavonoid derivatives via facile synthetic approaches since the research in flavonoids is useful for therapeutic and biotechnology fields.
黄酮类化合物属于多酚类，天然存在于水果、蔬菜、茶和谷物中。黄酮类化合物作为次生代谢产物，对生物过程以及植物对多种环境因素的反应具有不可或缺的作用。黄酮类化合物的生物活性取决于C6-C3-C6环取代模式，该模式具有生物活性抗氧化、抗菌、抗真菌、抗肿瘤和抗炎特性。已经通过各种方法报道了黄酮类化合物的合成。因此，由于黄酮类化合物的研究对治疗和生物技术领域有用，本综述系统地总结了通过简便合成方法合成近期杂环黄酮类衍生物的情况。
