State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Department of Burns and Wound Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
J Control Release. 2024 Jul;371:516-529. doi: 10.1016/j.jconrel.2024.06.013. Epub 2024 Jun 12.
Gene delivery has revolutionized conventional medical approaches to vaccination, cancer, and autoimmune diseases. However, current gene delivery methods are limited to either intravenous administration or direct local injections, failing to achieve well biosafety, tissue targeting, drug retention, and transfection efficiency for desired therapeutic outcomes. Transdermal drug delivery based on various delivery strategies can offer improved therapeutic potential and superior patient experiences. Recently, there has been increased foundational and clinical research focusing on the role of the transdermal route in gene delivery and exploring its impact on the efficiency of gene delivery. This review introduces the recent advances in transdermal gene delivery approaches facilitated by drug formulations and medical devices, as well as discusses their prospects.
基因传递技术已经彻底改变了传统的医学疫苗接种、癌症和自身免疫性疾病的治疗方法。然而，目前的基因传递方法仅限于静脉内给药或直接局部注射，无法实现良好的生物安全性、组织靶向性、药物保留和转染效率，以达到预期的治疗效果。基于各种传递策略的经皮药物传递系统为改善治疗效果和提高患者体验提供了可能。最近，越来越多的基础和临床研究集中在经皮给药途径在基因传递中的作用，并探讨其对基因传递效率的影响。本文综述了通过药物制剂和医疗设备实现的经皮基因传递方法的最新进展，并讨论了其前景。
