Xiang Boyu, Zhang Minghui, Li Dongjie
Department of Urology, Xiangya Hospital, Central South University, Changsha, China.
Department of Cardiology, Capital Medical University affiliated Beijing Anzhen Hospital, Beijing, China.
Transl Androl Urol. 2024 May 31;13(5):748-758. doi: 10.21037/tau-24-10. Epub 2024 May 28.
The association between psoriasis and erectile dysfunction (ED) is currently inconsistent in epidemiological and observational studies and the causal relationship between them has not been established. The aim of our study is to explore the potential genetic association between ED and psoriasis.
We explored the putative causality between psoriasis and ED by bidirectional Mendelian randomization (MR). The single nucleotide polymorphisms (SNPs) associated with psoriasis were retrieved from a large-scale public genome-wide association study (GWAS). The summary statistics of ED were obtained from individuals of European ancestry with 6,175 cases 217,630 controls. Inverse-variant weighted (IVW), weighted median (WM), MR-Egger, MR-Steiger, and MR pleiotropy residual sum and outlier (MR-PRESSO) test were employed in MR analyses to investigate the bidirectional causal relationship between psoriasis and ED. Several sensitivity analyses were employed to confirm the findings of the MR analysis.
Our MR analysis indicated that genetically predicted psoriasis showed no association with a higher risk of ED [odds ratio (OR) 2.878, 95% confidence interval (CI): 0.175-47.289, P=0.46]. As for the other direction, no causal association was disclosed between ED and psoriasis (OR 0.999, 95% CI: 0.997-1.002, P=0.62). These findings remained consistent in sensitivity analyses.
The study revealed a negative genetic association between psoriasis and ED. Certain acquired factors may contribute to a strong clinical connection between the two, highlighting the need for comprehensive management of these risk factors.
银屑病与勃起功能障碍（ED）之间的关联在流行病学和观察性研究中目前并不一致，且它们之间的因果关系尚未确立。我们研究的目的是探索ED与银屑病之间潜在的遗传关联。
我们通过双向孟德尔随机化（MR）探索银屑病与ED之间的假定因果关系。与银屑病相关的单核苷酸多态性（SNP）从大规模公共全基因组关联研究（GWAS）中检索。ED的汇总统计数据来自欧洲血统的个体，有6175例病例和217630例对照。在MR分析中采用逆方差加权（IVW）、加权中位数（WM）、MR-Egger、MR-Steiger和MR多效性残差和异常值（MR-PRESSO）检验来研究银屑病与ED之间的双向因果关系。采用了几种敏感性分析来确认MR分析的结果。
我们的MR分析表明，基因预测的银屑病与较高的ED风险无关[优势比（OR）2.878，95%置信区间（CI）：0.175 - 47.289，P = 0.46]。至于另一个方向，ED与银屑病之间未发现因果关联（OR 0.999，95% CI：0.997 - 1.002，P = 0.62）。这些发现在敏感性分析中仍然一致。
该研究揭示了银屑病与ED之间的负向遗传关联。某些后天因素可能导致两者之间有很强的临床联系，这突出了对这些风险因素进行综合管理的必要性。
