Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
PLoS One. 2024 Jun 10;19(6):e0304169. doi: 10.1371/journal.pone.0304169. eCollection 2024.
This study aimed to assess the effect of intraocular pressure (IOP) changes on biometry and intraocular lens (IOL) power calculation in patients diagnosed with primary open-angle glaucoma (POAG) and ocular hypertension (OHT). This prospective non-randomized cohort study enrolled patients with diagnosed POAG and OHT, presenting with IOP levels exceeding 25 mmHg. Thai Clinical Trials Registry number was TCTR20180912007. Optical biometry, encompassing measurements such as corneal thickness (CCT), keratometry, anterior chamber depth (ACD), and axial length, was conducted before and after IOP reduction. The IOL power was also determined using the SRK/T formula. The main outcomes measured were alterations in biometry and IOL power. Correlations between IOP, biometric parameters, and IOL power were analyzed. In total, 28 eyes were included in the study, with a mean patient age of 65.71±10.2 years. After IOP reduction, all biometric parameters, except CCT and ACD, exhibited a decrease without reaching statistical significance (all p>0.05). Meanwhile, IOL power showed a slight increase of 0.214±0.42 diopters (P = 0.035). The correlation between IOP and biometric parameters was found to be weak. However, there was a moderate correlation between IOP and IOL power (r2 = 0.267). Notably, IOL power tended to increase by more than 0.5 diopters when IOP decreased by more than 10 mmHg (p < 0.001). In conclusion, changes in IOP among patients with POAG and OHT do not significantly impact biometry and IOL power calculations. Nonetheless, it may be prudent to consider a slight adjustment in IOL power when IOP is lowered by more than 10 mmHg.
本研究旨在评估原发性开角型青光眼（POAG）和高眼压症（OHT）患者的眼压（IOP）变化对生物测量和人工晶状体（IOL）功率计算的影响。这项前瞻性非随机队列研究纳入了诊断为 POAG 和 OHT 的患者，这些患者的 IOP 水平超过 25mmHg。泰国临床试验注册编号为 TCTR20180912007。在降低 IOP 前后进行了光学生物测量，包括角膜厚度（CCT）、角膜曲率、前房深度（ACD）和眼轴等测量。还使用 SRK/T 公式确定了 IOL 功率。主要观察指标为生物测量和 IOL 功率的变化。分析了 IOP、生物测量参数和 IOL 功率之间的相关性。共有 28 只眼纳入研究，患者平均年龄为 65.71±10.2 岁。IOP 降低后，除 CCT 和 ACD 外，所有生物测量参数均有所下降，但无统计学意义（均 P>0.05）。同时，IOL 功率略有增加，为 0.214±0.42 屈光度（P=0.035）。IOP 与生物测量参数之间的相关性较弱，但与 IOL 功率之间存在中度相关性（r2=0.267）。值得注意的是，当 IOP 降低超过 10mmHg 时，IOL 功率增加超过 0.5 屈光度（p<0.001）。综上所述，POAG 和 OHT 患者的 IOP 变化不会显著影响生物测量和 IOL 功率计算。然而，当 IOP 降低超过 10mmHg 时，考虑对 IOL 功率进行轻微调整可能是谨慎的做法。
