Maury C P, Törnroth T, Teppo A M
Arthritis Rheum. 1985 Apr;28(4):388-94. doi: 10.1002/art.1780280406.
Gastric studies were carried out in 16 patients with well-documented Sjögren's syndrome (SS), 43 matched rheumatic disease patients without SS, and 7 patients with chronic atrophic gastritis not associated with SS. Chronic atrophic gastritis was a much more common finding in the SS patients than in the rheumatic disease control patients. Significant hypopepsinogenemia was present in 11 of 16 SS patients. In 6 patients this was combined with hypergastrinemia, a combination highly specific for chronic atrophic gastritis. The lowest pepsinogen levels were seen in patients with primary SS associated with high levels of SS-B antibody. On a histologic and biochemical basis, it was not possible to distinguish the gastric findings in primary SS from those in secondary SS, nor to distinguish chronic atrophic gastritis associated with SS from that not associated with SS. We conclude that chronic atrophic gastritis is a prominent feature in SS and that the severity of the gastritis appears to correlate with some serologic parameters of SS.
对16例有充分记录的干燥综合征（SS）患者、43例匹配的无SS的风湿性疾病患者以及7例与SS无关的慢性萎缩性胃炎患者进行了胃部研究。慢性萎缩性胃炎在SS患者中比在风湿性疾病对照患者中更为常见。16例SS患者中有11例存在显著的低胃蛋白酶原血症。6例患者同时伴有高胃泌素血症，这种组合对慢性萎缩性胃炎具有高度特异性。胃蛋白酶原水平最低的患者是伴有高水平SS - B抗体的原发性SS患者。从组织学和生化角度来看，无法区分原发性SS和继发性SS的胃部表现，也无法区分与SS相关的慢性萎缩性胃炎和与SS无关的慢性萎缩性胃炎。我们得出结论，慢性萎缩性胃炎是SS的一个突出特征，且胃炎的严重程度似乎与SS的一些血清学参数相关。
