Zhang Yiping, Xie Jun
School of Life Sciences, Fudan University, Shanghai, China.
Wanchuanhui (Shanghai) Medical Technology Co., Ltd., Shanghai, China.
Front Pharmacol. 2024 May 27;15:1374722. doi: 10.3389/fphar.2024.1374722. eCollection 2024.
Colorectal cancer (CRC) poses a significant global health challenge, ranking as the third most diagnosed cancer and the second leading cause of cancer-related deaths. Despite advancements in treatment, challenges such as delayed diagnosis, multidrug resistance, and limited therapeutic effectiveness persist, emphasizing the need for innovative approaches. This review explores the potential of natural products, nutraceuticals, and phytochemicals for targeting ferroptosis-related regulators as a novel strategy in CRC. Ferroptosis, a form of regulated cell death characterized by iron-dependent lethal lipid peroxide accumulation, holds substantial importance in CRC progression and therapy resistance. Natural products, known for their diverse bioactive effects and favorable safety profiles, emerge as promising candidates to induce ferroptosis in CRC cells. Exploring amino acid, iron, lipid metabolism regulators, and oxidative stress regulators reveals promising avenues for inducing cell death in CRC. This comprehensive review provides insights into the multifaceted effects of natural products on proteins integral to ferroptosis regulation, including GPX4, SLC7A11, ACSL4, NCOA4, and HO-1. By elucidating the intricate mechanisms through which natural products modulate these proteins, this review lays the foundation for a promising therapeutic strategy in CRC.
结直肠癌（CRC）是一项重大的全球健康挑战，是第三大最常被诊断出的癌症，也是癌症相关死亡的第二大主要原因。尽管治疗方面取得了进展，但诸如诊断延迟、多药耐药和治疗效果有限等挑战依然存在，这凸显了创新方法的必要性。本综述探讨了天然产物、营养保健品和植物化学物质作为CRC中一种新策略靶向铁死亡相关调节因子的潜力。铁死亡是一种受调控的细胞死亡形式，其特征是铁依赖性致命脂质过氧化物积累，在CRC进展和治疗耐药性中具有重要意义。天然产物以其多样的生物活性作用和良好的安全性而闻名，成为诱导CRC细胞铁死亡的有希望的候选物。探索氨基酸、铁、脂质代谢调节因子和氧化应激调节因子为诱导CRC细胞死亡揭示了有前景的途径。这篇全面的综述深入探讨了天然产物对铁死亡调节所必需的蛋白质的多方面影响，包括GPX4、SLC7A11、ACSL4、NCOA4和HO-1。通过阐明天然产物调节这些蛋白质的复杂机制，本综述为CRC中一种有前景的治疗策略奠定了基础。
