Department of Pediatric Infection, Faculty of Medicine, Cukurova University, Adana, Turkey.
Department of Child Health and Diseases, Faculty of Medicine, Cukurova University, Adana, Turkey.
Microbiol Spectr. 2024 Jul 2;12(7):e0056424. doi: 10.1128/spectrum.00564-24. Epub 2024 Jun 12.
In recent years, the incidence and drug resistance of have increased. Our study aimed to determine the antifungal sensitivity of and the clinical and demographic characteristics of children with candidemia. Two hundred pediatric patients with candidemia were included in the study between 1 January 2010 and 1 August 2023. Clinical samples were evaluated on a BACTEC-FX-40 automatic blood culture device (Becton Dickinson, USA). Yeast isolates were identified to the species level via identification cards (YST) using the VITEK 2 Compact (bioMeriéux, France) system. Antifungal susceptibility was performed using antifungal cell cards (AST-YST01). Approval for the study was received from the "University Faculty of Medicine" Hospital Clinical Research Ethics Committee. Non-catheter candidemia was detected in 127 (63.5%) patients, and catheter-related candidemia was detected in 73 (36.5%) patients. It was observed that the patients' history of malignancy, mechanical ventilation, urinary catheter, nasogastric tube, and intensive care unit stay was associated with mortality. The mortality rate from candidemia was 9.5%. The most frequently preferred antifungal agents were amphotericin B and fluconazole. The fluconazole drug resistance rate was found to be 6%, and the amphotericin B drug resistance rate was 4%. Because candidemia mortality rates can be high depending on risk factors and clinical characteristics, it is important to initiate appropriate and timely antifungal therapy. We think that our study can provide important information about the clinical profiles, distributions, susceptibility profiles, and control of antifungal resistance of isolates.
It has been observed that the frequency and antifungal resistance of have increased recently. In our study, we aimed to determine the antifungal sensitivity of and the clinical and demographic characteristics of children with candidemia. It was observed that the patients' history of malignancy, mechanical ventilation, urinary catheter, nasogastric tube, and intensive care stay was associated with mortality. The mortality rate from candidemia was 9.5%. The most frequently preferred antifungal agents were amphotericin B and fluconazole. The fluconazole drug resistance rate was found to be 6%, and the amphotericin B drug resistance rate was 4%. Because candidemia mortality rates can be high depending on risk factors and clinical characteristics, it is important to initiate appropriate and timely antifungal therapy.
近年来， 的发病率和耐药率有所增加。我们的研究旨在确定 的抗真菌敏感性以及儿童念珠菌血症的临床和人口统计学特征。
本研究纳入了 2010 年 1 月 1 日至 2023 年 8 月 1 日期间 200 例患有念珠菌血症的儿科患者。临床样本在 BACTEC-FX-40 自动血培养仪（Becton Dickinson，美国）上进行评估。使用 VITEK 2 Compact（生物梅里埃，法国）系统通过鉴定卡（YST）将酵母分离株鉴定到种水平。使用抗真菌细胞卡（AST-YST01）进行抗真菌药敏试验。该研究获得了“大学医学院”医院临床研究伦理委员会的批准。
127 例（63.5%）患者为非导管相关性念珠菌血症，73 例（36.5%）患者为导管相关性念珠菌血症。观察到患者的恶性肿瘤病史、机械通气、导尿管、鼻胃管和重症监护病房停留与念珠菌血症死亡率相关。念珠菌血症的死亡率为 9.5%。最常首选的抗真菌药物为两性霉素 B 和氟康唑。氟康唑耐药率为 6%，两性霉素 B 耐药率为 4%。由于念珠菌血症的死亡率可能取决于危险因素和临床特征，因此及时给予适当的抗真菌治疗非常重要。我们认为我们的研究可以提供有关 分离株的临床特征、分布、药敏谱和抗真菌耐药性控制的重要信息。
