Ebersole J L, Taubman M A, Smith D J, Haffajee A D
Infect Immun. 1985 May;48(2):534-9. doi: 10.1128/iai.48.2.534-539.1985.
The effects of scaling and root planing treatment on systemic antibody responses were studied in patients with periodontal disease and in normal subjects. Immunoglobulin G antibody in serum to a battery of oral microorganisms was assessed in an enzyme-linked immunosorbent assay before and after treatment in 31 individuals. The majority (96%) of the diseased patients exhibited elevated antibody to one or more of the microorganisms before the scaling regime. Significant increases in antibody levels in serum were noted in 16 of 19 patients after scaling, whereas only 2 of 12 nonscaled subjects showed similar changes during monitoring intervals of up to 3 years. The bacterial specificities of the increases were found to differ among the patients; however, a significant correlation to preexisting elevated antibody levels was observed. Peak levels of responses were noted at approximately 2 to 4 months posttreatment; antibody returned to pretreatment levels by 8 to 12 months. The predominant organisms for which changes were noted included the black-pigmented Bacteroides spp., Eikenella corrodens, Campylobacter concisus, and Actinobacillus actinomycetemcomitans. In 18 of 19 instances, the homologous microorganism was detected in the subgingival plaque when elevated antibody was present after treatment. These findings indicated that specific changes in host systemic responses accompany scaling and root planing treatment of periodontal disease patients. These alterations in the host response may provide an additional means by which successful therapy can be accomplished.
在牙周病患者和正常受试者中研究了龈上洁治和根面平整治疗对全身抗体反应的影响。采用酶联免疫吸附测定法，在治疗前后对31名个体血清中针对一系列口腔微生物的免疫球蛋白G抗体进行了评估。在进行洁治之前，大多数（96%）患病患者表现出针对一种或多种微生物的抗体升高。19名患者中有16名在洁治后血清抗体水平显著升高，而在长达3年的监测期内，12名未进行洁治的受试者中只有2名出现了类似变化。发现抗体升高的细菌特异性在患者之间存在差异；然而，观察到与先前升高的抗体水平存在显著相关性。治疗后约2至4个月出现抗体反应峰值水平；抗体在8至12个月时恢复到治疗前水平。观察到抗体变化的主要微生物包括产黑色素类杆菌属、啮蚀艾肯菌、简明弯曲菌和伴放线放线杆菌。在19例中的18例中，治疗后出现抗体升高时，在龈下菌斑中检测到了同源微生物。这些发现表明，牙周病患者进行龈上洁治和根面平整治疗会伴随宿主全身反应的特异性变化。宿主反应的这些改变可能为成功治疗提供了一种额外的途径。
