Spencer H, Kramer L
J Am Coll Nutr. 1985;4(1):121-8. doi: 10.1080/07315724.1985.10720071.
A gradual loss of bone occurs with age. There are indications in the literature that not only calcium but also fluoride may play an important role in maintaining the bone mass. In view of the high incidence of osteoporosis and its complications, and in view of the fact that fluoride is beneficial for the treatment of osteoporosis, studies have been carried out in this research unit to determine the retention and excretion of fluoride both during a normal dietary intake of fluoride and during fluoride supplementation. Another problem to be examined was to delineate whether certain substances interfere with the intestinal absorption of fluoride and of calcium. One such substance is aluminum contained in commonly used antacids. The use of small amounts of aluminum-containing antacids increased fecal fluoride significantly, thereby decreasing the intestinal absorption of fluoride. In addition, the small doses of aluminum-containing antacids also affected the metabolism of calcium and phosphorus, the primary effect being complexation of phosphorus in the intestine leading to phosphorus depletion. This change in phosphorus metabolism was associated with an increase of the urinary and fecal calcium excretion resulting in a negative calcium balance. The dual effect of aluminum, namely in causing calcium loss and inhibition of the intestinal absorption of fluoride, can result in adverse effects on bone which may contribute to bone loss.
随着年龄增长，骨质会逐渐流失。文献表明，不仅钙，氟化物在维持骨量方面也可能发挥重要作用。鉴于骨质疏松症及其并发症的高发病率，以及氟化物对骨质疏松症治疗有益这一事实，本研究单位开展了多项研究，以确定在正常饮食摄入氟化物以及补充氟化物期间氟化物的潴留和排泄情况。另一个需要研究的问题是确定某些物质是否会干扰氟化物和钙的肠道吸收。常用抗酸剂中含有的铝就是这样一种物质。使用少量含铝抗酸剂会显著增加粪便中的氟含量，从而降低氟化物的肠道吸收。此外，小剂量含铝抗酸剂还会影响钙和磷的代谢，主要作用是使肠道中的磷络合，导致磷缺乏。这种磷代谢的变化与尿钙和粪钙排泄增加有关，从而导致钙平衡为负。铝的双重作用，即导致钙流失和抑制氟化物的肠道吸收，可能会对骨骼产生不利影响，进而导致骨质流失。
