Tran Quyen H N, Nguyen Huong T M, Nguyen Tri H, Nguyen Thuy T L, Sichaem Jirapast, Do Lien T M
Sai Gon University, Ho Chi Minh City, Vietnam.
Department of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, Vietnam.
Nat Prod Res. 2024 Jun 13:1-6. doi: 10.1080/14786419.2024.2367011.
Two previously unreported xanthones, xanthoschomes A and B ( and ), along with six known xanthones, -mangostin (), -mangostin (), -mangostin (), garcinone C (), 2-(,-dimethylallyl)-1,7-dihydroxy-3-methoxyxanthone (), and dulxanthone D (), have been isolated from the fruits of Vietnamese The structures of all isolated compounds were fully characterised using spectroscopic data and comparison with the previous literature. All isolated compounds were evaluated for their -glucosidase inhibitory activity. Compounds demonstrated effective -glucosidase inhibition, with the IC ranging from 2.91 to 26.0 M, outperforming the standard acarbose (IC 179 M). Among these isolated compounds, compound exhibited the highest inhibitory activity against -glucosidase, with an IC value of 2.91 M.
从越南[植物名称未给出]的果实中分离出了两种此前未报道的呫吨酮类化合物，即呫吨酮舒姆斯A和B（以及），以及六种已知的呫吨酮类化合物，α-山竹黄酮（）、β-山竹黄酮（）、γ-山竹黄酮（）、藤黄诺酮C（）、2-(α,β-二甲基烯丙基)-1,7-二羟基-3-甲氧基呫吨酮（）和杜尔呫吨酮D（）。所有分离得到的化合物的结构均通过光谱数据并与先前文献进行比较得到了充分表征。对所有分离得到的化合物进行了α-葡萄糖苷酶抑制活性评估。化合物表现出有效的α-葡萄糖苷酶抑制作用，IC50范围为2.91至26.0μM，优于标准药物阿卡波糖（IC50为179μM）。在这些分离得到的化合物中，化合物对α-葡萄糖苷酶表现出最高的抑制活性，IC50值为2.91μM。
