School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
Cell Signal. 2024 Sep;121:111260. doi: 10.1016/j.cellsig.2024.111260. Epub 2024 Jun 12.
Growth hormone-releasing hormone antagonists (GHRHAnt) have been associated with antitumor and antioxidative activities. The present study investigates for the first time the effects of those compounds towards pro-inflammatory cytokine expression in a murine model of cecal ligation and puncture (CLP) - induced sepsis. The results indicate that GHRHAnt JV-1-36 significantly suppressed IL-1α, IL-6, and pSTAT3 activation in septic lungs. Moreover, GHRHAnt treatment reduced bronchoalveolar lavage fluid (BALF) protein concentration, suggesting a protective effect of that compound in sepsis-induced lung edema. Based on those findings, it is suggested that GHRHAnt may represent an exciting new therapeutic possibility in sepsis-induced endotoxemia and lung injury.
生长激素释放激素拮抗剂（GHRHAnt）已被证明具有抗肿瘤和抗氧化作用。本研究首次探讨了这些化合物在盲肠结扎和穿刺（CLP）诱导的脓毒症小鼠模型中对促炎细胞因子表达的影响。结果表明，GHRHAnt JV-1-36 可显著抑制脓毒症肺组织中 IL-1α、IL-6 和 pSTAT3 的激活。此外，GHRHAnt 治疗可降低支气管肺泡灌洗液（BALF）蛋白浓度，表明该化合物对脓毒症诱导的肺水肿具有保护作用。基于这些发现，建议 GHRHAnt 可能代表一种新的治疗脓毒症性内毒素血症和肺损伤的治疗可能性。
