School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, 1800 Bienville Drive, Monroe, LA, 71201, USA.
Inflamm Res. 2022 Feb;71(2):183-185. doi: 10.1007/s00011-021-01531-5. Epub 2022 Jan 7.
Growth Hormone-Releasing Hormone (GHRH) is a neuropeptide regulating the release of Growth Hormone (GH) from the anterior pituitary gland, and acts as a growth factor in a diverse variety of tissues. GHRH antagonists (GHRHAnt) have been developed to counteract those events, and the beneficial effects of those peptides toward homeostasis have been associated with anti-inflammatory activities. Our lab is interested in delineating the mechanisms governing endothelial barrier function. Our goal is to establish new grounds on the development of efficient countermeasures against Acute Respiratory Distress Syndrome (ARDS), which has been associated with thousands of deaths worldwide due to COVID-19. Herein we demonstrate in vivo that GHRHAnt suppresses LPS-induced increase in bronchoalveolar lavage fluid (BALF) protein concentration, thus protecting the lungs against edema and inflammation.
生长激素释放激素（GHRH）是一种神经肽，可调节生长激素（GH）从前垂体的释放，并且在多种组织中充当生长因子。已经开发出生长激素释放激素拮抗剂（GHRHAnt）来对抗这些事件，并且这些肽对体内平衡的有益作用与抗炎活性有关。我们的实验室有兴趣阐明调节内皮屏障功能的机制。我们的目标是为急性呼吸窘迫综合征（ARDS）的有效对策的发展奠定新的基础，由于 COVID-19，ARDS 导致全世界有数千人死亡。在此，我们在体内证明了 GHRHAnt 可抑制 LPS 诱导的支气管肺泡灌洗液（BALF）蛋白浓度增加，从而保护肺部免受水肿和炎症的侵害。
