Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, 30-688 Krakow, Poland; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, św. Łazarza 15, 31-530 Krakow, Poland; Istituto Pasteur Italia, Fondazione Cenci-Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Istituto Pasteur Italia, Fondazione Cenci-Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Drug Discov Today. 2024 Aug;29(8):104062. doi: 10.1016/j.drudis.2024.104062. Epub 2024 Jun 11.
Neurodegenerative diseases are challenging to cure. To date, no cure has been found for Alzheimer's disease or Parkinson's disease, and current treatments are able only to slow the progression of the diseases and manage their symptoms. After an introduction to the complex biology of these diseases, we discuss the beneficial effect of selenium-containing agents, which show neuroprotective effects in vitro or in vivo. Indeed, selenium is an essential trace element that is being incorporated into innovative organoselenium compounds, which can improve outcomes in rodent or even primate models with neurological deficits. Herein, we critically discuss recent findings in the field of selenium-based applications in neurological disorders.
神经退行性疾病难以治愈。迄今为止，尚无治愈阿尔茨海默病或帕金森病的方法，目前的治疗方法只能减缓疾病的进展并控制其症状。在介绍了这些疾病的复杂生物学特性之后，我们讨论了含硒试剂的有益作用，这些试剂在体外或体内具有神经保护作用。事实上，硒是一种必需的微量元素，它被整合到创新的有机硒化合物中，可以改善具有神经缺陷的啮齿动物甚至灵长类动物模型的结果。在这里，我们批判性地讨论了神经紊乱领域中基于硒的应用的最新发现。
