Dou Zhili, Shi Yanyan, Jia Jinzhu
Department of Biostatistics, School of Public Health, Peking University, Beijing, China.
Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China.
Front Oncol. 2024 May 28;14:1412243. doi: 10.3389/fonc.2024.1412243. eCollection 2024.
The purpose of this study is to assess the burden of thyroid cancer over the course of 30 years in 204 countries and territories.
Data from the Global Burden of Disease (GBD) 2019 database was analyzed to extract information on prevalence, deaths, DALYs(disability-adjusted life-years), YLL(years of life los), YLD(years lived with disability), and their corresponding age-standardized rates at global, regional, and national levels. The primary focus of the study was to examine trends in thyroid cancer from 1990 to 2019, specifically looking at the Estimated Annual Percentage Change (EAPC) for ASPR, ASDR, and ASDR. Additionally, the study investigated the relationship between cancer burden and the Socio-Demographic Index (SDI).
Globally, there will be approximately 18.3 million thyroid cancer (TC) cases in 2019; China and the USA are projected to be the most significant with 310,327 and 220,711 cases (16.17 and 14.82 cases per 100,000 people, respectively).Over the period from 1990 to 2019, age-standardized prevalence rates exhibited a global rise, whereas deaths and DALYs saw a decrease(EAPC:1.63, -0.15- -0.14, respectively). Significantly, the age-standardized prevalence rate increased in 21 GBD regions, affecting 195 out of 204 countries or territories. Over the studied period, thyroid cancer cases, deaths, and DALYs were consistently higher among females than males. Furthermore, a higher Socio-demographic Index was associated with increased age-standardized prevalence rates.
本研究旨在评估204个国家和地区30年间的甲状腺癌负担。
分析全球疾病负担（GBD）2019数据库中的数据，以提取全球、区域和国家层面的患病率、死亡人数、伤残调整生命年（DALYs）、生命损失年（YLL）、带病生存年（YLD）及其相应的年龄标准化率信息。该研究的主要重点是考察1990年至2019年甲状腺癌的趋势，特别是观察年龄标准化患病率（ASPR）、年龄标准化死亡率（ASDR）和年龄标准化伤残调整率（ASDR）的估计年百分比变化（EAPC）。此外，该研究还调查了癌症负担与社会人口指数（SDI）之间的关系。
2019年全球甲状腺癌（TC）病例约1830万例；预计中国和美国的病例数最多，分别为310327例和220711例（每10万人中分别为16.17例和14.82例）。1990年至2019年期间，全球年龄标准化患病率呈上升趋势，而死亡人数和伤残调整生命年则有所下降（EAPC分别为1.63、-0.15和-0.14）。值得注意的是，21个GBD区域的年龄标准化患病率有所上升，影响了204个国家或地区中的195个。在研究期间，女性的甲状腺癌病例、死亡人数和伤残调整生命年一直高于男性。此外，较高的社会人口指数与年龄标准化患病率的增加有关。
