School of Public Health, University of British Columbia, 2206 East Mall, Vancouver, V6T 1Z3, BC, Canada.
School of Public Health, University of British Columbia, 2206 East Mall, Vancouver, V6T 1Z3, BC, Canada.
Spat Spatiotemporal Epidemiol. 2024 Jun;49:100658. doi: 10.1016/j.sste.2024.100658. Epub 2024 May 15.
The gap between the reported and actual COVID-19 infection cases has been an issue of concern. Here, we present Bayesian hierarchical spatiotemporal disease mapping models for state-level predictions of COVID-19 infection risks and (under)reporting rates among people aged 65 and above during the first two years of the pandemic in the United States. With prior elicitation based on recent prevalence studies, the study suggests that the median state-level reporting rate of COVID-19 infection was 90% (interquartile range: [78%, 96%]). Our study uncovers spatiotemporal variations and dynamics in state-level infection risks and (under)reporting rates, suggesting time-varying associations between higher population density, higher percentage of minorities, and higher percentage of vaccination and increased risks of COVID-19 infection, as well as an association between more easily accessible tests and higher reporting rates. With sensitivity analyses, we highlight the impact and importance of incorporating covariates information and objective prior references for evaluating the issue of underreporting.
报告和实际 COVID-19 感染病例之间的差距一直是人们关注的问题。在这里,我们提出了贝叶斯分层时空疾病映射模型,用于预测美国大流行前两年 65 岁及以上人群 COVID-19 感染风险和(漏报)率。基于最近流行率研究的先验推断,该研究表明,COVID-19 感染的中位州级漏报率为 90%(四分位间距:[78%,96%])。我们的研究揭示了州级感染风险和(漏报)率的时空变化和动态,表明人口密度较高、少数民族比例较高、疫苗接种比例较高与 COVID-19 感染风险增加之间存在时变关联,以及更容易获得检测与更高报告率之间存在关联。通过敏感性分析,我们强调了纳入协变量信息和客观先验参考的重要性,以评估漏报问题。