Federal Center for Animal Health, 600901, Vladimir, Russia.
Agricultural Research Council-Onderstepoort Veterinary Institute, 100 Old Soutpan Road, 0110, Onderstepoort, South Africa.
Arch Virol. 2024 Jun 15;169(7):147. doi: 10.1007/s00705-024-06064-w.
African swine fever virus (ASFV) isolates are grouped and tracked through analysis of their central variable region (CVR) sequences. In this study, sequences of 70 ASFV isolates collected from different regions of Russia between 2018 and 2022 were analyzed. The analysis based on the CVR sequences indicated that the isolates belonged to three distinct groups. Group 1 shared 100% sequence identity to the isolate Georgia 2007/1. Group 5 had a C > A single-nucleotide polymorphism (SNP) at position 601, while group 13 is new and unique to the Far East of Russia, with five isolates from the Amur, Khabarovsk, and Primorsky regions. These findings demonstrate a new approach to phylogenomics and cladistics of ASFV isolates within genotype II on the basis of the CVR.
非洲猪瘟病毒（ASFV）分离株通过对其中心可变区（CVR）序列的分析进行分组和跟踪。在这项研究中，分析了 2018 年至 2022 年间从俄罗斯不同地区收集的 70 个 ASFV 分离株的序列。基于 CVR 序列的分析表明，这些分离株属于三个不同的组。组 1 与 2007/1 年的格鲁吉亚分离株完全相同。组 5 在位置 601 处有一个 C > A 单核苷酸多态性（SNP），而组 13 是俄罗斯远东地区特有的新组，有来自阿穆尔、哈巴罗夫斯克和滨海边疆区的五个分离株。这些发现展示了一种新的方法，基于 CVR 对基因型 II 内的 ASFV 分离株进行系统发生和系统发育分析。
