Department of Cardiology, The First Hospital of Putian City, Putian, Fujian, China.
Front Endocrinol (Lausanne). 2024 Jun 3;15:1394383. doi: 10.3389/fendo.2024.1394383. eCollection 2024.
Serum testosterone is intrinsically associated to cardiovascular disease. Our aim is to explore the relationship between the recently updated cardiovascular health measurement, known as Life's Essential 8 (LE8), and the prevalence of testosterone deficiency (TD) in adult males in the United States.
Study data was obtained from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2016. A weighted multivariate logistic regression model was applied to evaluate the correlation between LE8 and testosterone deficiency. Restricted Cubic Spline (RCS) was employed to explore its non-linear relationship. In addition, a stratified analysis was conducted.
The final analysis included 2332 participants from NHANES from 2011 to 2016. After adjusting for confounding factors, the odds ratios (ORs) and 95% confidence intervals (CIs) for testosterone deficiency in participants with moderate and higher LE8 scores compared to the lowest LE8 scores were 0.59 (0.38-0.92) and 0.38 (0.19-0.76), respectively. The results of subgroup analysis showed that LE8 score was significantly associated with TD among young and middle-aged participants.
A lower LE8 score is related to a higher incidence of testosterone deficiency, especially in young and middle-aged men. Further research is necessary to explore the potential mechanisms between them.
血清睾酮与心血管疾病有内在联系。我们的目的是探讨最近更新的心血管健康测量方法，即“生命的八大要素”（LE8），与美国成年男性睾酮缺乏症（TD）的患病率之间的关系。
研究数据来自 2011 年至 2016 年的国家健康和营养检查调查（NHANES）。应用加权多变量逻辑回归模型评估 LE8 与睾酮缺乏症之间的相关性。采用限制三次样条（RCS）探索其非线性关系。此外，还进行了分层分析。
最终分析包括来自 2011 年至 2016 年 NHANES 的 2332 名参与者。在调整混杂因素后，LE8 评分中等及以上与 LE8 评分最低的参与者相比，睾酮缺乏症的比值比（ORs）和 95%置信区间（CIs）分别为 0.59（0.38-0.92）和 0.38（0.19-0.76）。亚组分析结果表明，LE8 评分与中青年参与者的 TD 显著相关。
较低的 LE8 评分与较高的睾酮缺乏症发病率相关，尤其是在年轻和中年男性中。需要进一步研究探讨它们之间的潜在机制。
