Department of Chemical Sciences, Universityof Naples "Federico II", Italy.
Department of Chemical, Materialsand Industrial Production Engineering, University of Naples Federico II, Italy; Center for Advanced Biomaterials for Healthcare, Istituto Italiano di Tecnologia (IIT@CRIB), Italy.
Carbohydr Polym. 2020 Apr 1;233:115839. doi: 10.1016/j.carbpol.2020.115839. Epub 2020 Jan 13.
Wound healing can lead to complex clinical problems, hence finding an efficient approach to enhance the healing process is necessary. An ideal wound dressing should treat wounds at reasonable costs, with minimal inconveniences for the patient. Chitosan is one of the most investigated biopolymers for wound healing applications due to its biocompatibility, biodegradability, non-toxicity, and antimicrobial activity. Moreover, chitosan and its derivative have attracted numerous attentions because of the accelerating wound healing, and easy processability into different forms (gels, foams, membranes, and beads). All these properties make chitosan-based materials particularly versatile and promising for wound dressings. Besides, secondary natural metabolites could potentially act like the antimicrobial and anti-inflammatory agents and accelerate the healing process. This review collected almost all studies regarding natural compounds applications in wound healing by focusing on the chitosan-based bioactive wound dressing systems. An accurate analysis of different chitosan formulations and the influence of bioactive compounds on their wound healing properties are reported.
伤口愈合可能会导致复杂的临床问题，因此需要寻找一种有效的方法来促进愈合过程。理想的伤口敷料应在合理的成本下治疗伤口，尽量减少对患者的不便。壳聚糖由于其生物相容性、可生物降解性、无毒性和抗菌活性，是研究最多的用于伤口愈合应用的生物聚合物之一。此外，壳聚糖及其衍生物因其能够加速伤口愈合以及易于加工成不同形式（凝胶、泡沫、膜和珠）而引起了广泛关注。所有这些特性使得基于壳聚糖的材料在伤口敷料方面具有特别广泛的应用前景。此外，次生天然代谢产物可能具有抗菌和抗炎作用，并能加速愈合过程。本综述收集了几乎所有关于天然化合物在伤口愈合中的应用的研究，重点是基于壳聚糖的生物活性伤口敷料系统。报告了对不同壳聚糖配方的准确分析以及生物活性化合物对其伤口愈合性能的影响。
