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印度的贫血症及其流行情况和多因素病因学:叙述性综述。

Anaemia in India and Its Prevalence and Multifactorial Aetiology: A Narrative Review.

机构信息

Institute for Food, Nutrition and Health, University of Reading, Reading RG6 5EU, UK.

School of Applied Sciences, University of Lilongwe, Area 15, Lilongwe P.O. Box 1614, Malawi.

出版信息

Nutrients. 2024 May 29;16(11):1673. doi: 10.3390/nu16111673.

Abstract

The prevalence of anaemia in India remains high in children, especially those in rural areas, and in women of childbearing age, and its impairment of neurological development can have serious lifelong effects. It is concerning that the most recent official data (2019-21) indicate an increased prevalence compared with 2015-16. There is also considerable variability in childhood anaemia between Indian states with socioeconomic factors, such as wealth and education contributing to the risk of anaemia among adolescent women and their children. Dietary iron deficiency is often regarded as the main contributor to anaemia but increasing evidence accumulated from the authors' ongoing literature database coupled with recent literature research suggests that it has a multifactorial aetiology, some of which is not related to nutrition. This narrative review focused on these multifactorial issues, notably the contribution of vitamin B/folate deficiency, which also has a high prevalence in India. It was also noted that the dietary intake of bioavailable iron remains an important contributor for reducing anaemia, and the role of millets as an improved iron source compared to traditional staple cereals is briefly discussed. The overall conclusion is that anaemia has a multifactorial aetiology requiring multifactorial assessment that must include assessment of vitamin B status.

摘要

印度儿童、尤其是农村地区儿童和育龄妇女贫血的患病率仍然很高,其对神经发育的损害可能会产生严重的终身影响。令人担忧的是,最近的官方数据(2019-21 年)显示,与 2015-16 年相比,贫血的患病率有所增加。印度各邦之间儿童贫血的情况也存在很大差异,社会经济因素(如财富和教育)会增加青少年妇女及其子女患贫血的风险。饮食中铁缺乏通常被认为是导致贫血的主要原因,但作者正在进行的文献数据库中积累的越来越多的证据以及最近的文献研究表明,贫血具有多因素病因,其中一些与营养无关。本叙述性综述重点关注这些多因素问题,尤其是维生素 B/叶酸缺乏的影响,印度此类缺乏症的患病率也很高。此外,还注意到可利用铁的膳食摄入量仍然是减少贫血的一个重要因素,并简要讨论了小米作为比传统主食更优的铁源的作用。总的结论是,贫血具有多因素病因,需要进行多因素评估,其中必须包括维生素 B 状况评估。

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