Department of Chemical Engineering, Pohang University of Science and Engineering (POSTECH), Pohang 37673, Republic of Korea.
Department of Environmental Science and Engineering, Pohang University of Science and Engineering (POSTECH), Pohang 37673, Republic of Korea; Department of Chemical Engineering, University of Khartoum, Khartoum 11115, Sudan.
J Colloid Interface Sci. 2024 Nov;673:647-656. doi: 10.1016/j.jcis.2024.06.114. Epub 2024 Jun 15.
Monodisperse nanoparticles of biodegradable polyhydroxyalkanoates (PHAs) polymers, copolymers of 3-hydroxybutyrate (3HB) and 4-hydroxybutyrate (4HB), are synthesized using a membrane-assisted emulsion encapsulation and evaporation process for biomedical resorbable adhesives. The precise control over the diameter of these PHA particles, ranging from 100 nm to 8 μm, is achieved by adjusting the diameter of emulsion or the PHA concentration. Mechanical properties of the particles can be tailored based on the 3HB to 4HB ratio and molecular weight, primarily influenced by the level of crystallinity. These monodisperse PHA particles in solution serve as adhesives for hydrogel systems, specifically those based on poly(N, N-dimethylacrylamide) (PDMA). Semi-crystalline PHA nanoparticles exhibit stronger adhesion energy than their amorphous counterparts. Due to their self-adhesiveness, adhesion energy increases even when those PHA nanoparticles form multilayers between hydrogels. Furthermore, as they degrade and are resorbed into the body, the PHA nanoparticles demonstrate efficacy in in vivo wound closure, underscoring their considerable impact on biomedical applications.
采用膜辅助乳液包封和蒸发工艺，可合成单分散纳米级可生物降解聚羟基烷酸酯（PHA）聚合物，即 3-羟基丁酸酯（3HB）和 4-羟基丁酸酯（4HB）的共聚物，可用于生物医学可吸收性胶粘剂。通过调节乳液的直径或 PHA 的浓度，可以精确控制这些 PHA 粒子的直径，范围从 100nm 到 8μm。粒子的机械性能可以根据 3HB 与 4HB 的比例和分子量进行调整，主要受结晶度水平的影响。这些单分散 PHA 粒子在溶液中可用作水凝胶体系的胶粘剂，特别是基于聚（N，N-二甲基丙烯酰胺）（PDMA）的水凝胶体系。半结晶 PHA 纳米粒子表现出比无定形粒子更强的粘附能。由于其自粘性，即使 PHA 纳米粒子在水凝胶之间形成多层，粘附能也会增加。此外，随着它们的降解和被吸收到体内，PHA 纳米粒子在体内伤口闭合方面表现出了功效，这突出了它们在生物医学应用方面的重要影响。
