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一项关于根管封闭剂和一种抗生素的评估，以评估它们对……的抗菌效果。

An evaluation of endodontic sealers and an antibiotic to assess their antimicrobial effect against .

作者信息

Madla-Cruz Elizabeth, Villanueva-Pérez Vanascheck Dasaev, De la Garza-Ramos Myriam A, Flores-Treviño Jorge Jaime, Rodríguez-Delgado Idalia, López-Martinez Fanny

机构信息

Universidad Autónoma de Nuevo Leon, Facultad de Odontología, Calle Dr. Aguirre Pequeño and Silao, Colonia Mitras Centro, Monterrey, Nuevo Leon, Mexico CP 64460.

出版信息

Biomater Investig Dent. 2024 May 24;11:40646. doi: 10.2340/biid.v11.40646. eCollection 2024.

DOI:10.2340/biid.v11.40646
PMID:38903776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11187975/
Abstract

OBJECTIVE

This study aimed to compare the antimicrobial effect of three endodontic sealers (AH Plus, Mineral trioxide aggregate [MTA] Fillapex, and BioRoot RCS) with and without amoxicillin against .

METHODOLOGY

Amoxicillin, equivalent to 10% of the sealers' total weight, was mixed with the sealers. Another batch was prepared without amoxicillin. The direct contact test (DCT) and the agar diffusion test were used to assess the antibacterial effect. Results were analysed using one-way analysis of variance (ANOVA), the F-test, and the Kruskal-Wallis test.

RESULTS

AH Plus significantly suppressed without the addition of amoxicillin in the DCT (p = 0.011), while in the agar diffusion test, BioRoot RCS had a larger inhibition zone than the control (p < 0.001). When amoxicillin was added to the sealers, AH Plus (p = 0.003) and MTA Fillapex (p = 0.042) reduced growth. In contrast, all three sealers showed larger inhibition zones than the control (p = 0.001), with AH Plus displaying a larger inhibition zone than MTA Fillapex (p = 0.042) and BioRoot RCS (p = 0.032).

CONCLUSIONS

It was thus concluded that the addition of amoxicillin to endodontic sealers enhances their antimicrobial activity against .

摘要

目的

本研究旨在比较三种根管封闭剂（AH Plus、矿物三氧化物凝聚体[MTA] Fillapex和BioRoot RCS）在添加和不添加阿莫西林的情况下对……的抗菌效果。

方法

将相当于封闭剂总重量10%的阿莫西林与封闭剂混合。制备另一批不添加阿莫西林的样品。采用直接接触试验（DCT）和琼脂扩散试验评估抗菌效果。使用单因素方差分析（ANOVA）、F检验和Kruskal-Wallis检验分析结果。

结果

在DCT中，AH Plus在不添加阿莫西林的情况下能显著抑制……（p = 0.011），而在琼脂扩散试验中，BioRoot RCS的抑菌圈比对照组大（p < 0.001）。当向封闭剂中添加阿莫西林时，AH Plus（p = 0.003）和MTA Fillapex（p = 0.042）能减少……的生长。相比之下，所有三种封闭剂的抑菌圈都比对照组大（p = 0.001），其中AH Plus的抑菌圈比MTA Fillapex（p = 0.042）和BioRoot RCS（p = 0.032）的抑菌圈大。

结论

因此得出结论，在根管封闭剂中添加阿莫西林可增强其对……的抗菌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/472e/11187975/864394bdf5d5/BIiD-11-40646-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/472e/11187975/bcb2fe61f78c/BIiD-11-40646-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/472e/11187975/864394bdf5d5/BIiD-11-40646-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/472e/11187975/bcb2fe61f78c/BIiD-11-40646-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/472e/11187975/864394bdf5d5/BIiD-11-40646-g002.jpg

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