Chen Jintao, Liu Chuanfeng, Sun Cunwei, Zeng Jia, Chi Jingwei, Che Kui, Wang Yangang
Department of Endocrinology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Int J Endocrinol. 2024 Jun 11;2024:3830246. doi: 10.1155/2024/3830246. eCollection 2024.
The aim of this study was to investigate the association between serum phosphate levels and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).
The study sample consisted of 1657 T2DM patients hospitalized between 2017 and 2019. Patients were categorized into quartiles based on their serum phosphate levels (Q1-Q4). An increasing trend in the prevalence of DR was observed across these quartiles. Subsequently, logistic regression analysis was employed to adjust for potential confounders, such as gender, age, BMI, and duration of diabetes, and to evaluate the odds ratios (ORs) associated with these quartiles. The prevalence of DR showed an increasing trend with elevated serum phosphate levels. Logistic regression further confirmed that serum phosphate levels remain an independent risk factor for DR.
Elevated serum phosphate levels are closely associated with the prevalence of DR in hospitalized T2DM patients. Further studies are needed to establish causality. This trial is registered with chiCTR2000032374.
本研究旨在探讨2型糖尿病（T2DM）患者血清磷酸盐水平与糖尿病视网膜病变（DR）之间的关联。
研究样本包括2017年至2019年间住院的1657例T2DM患者。根据血清磷酸盐水平（Q1-Q4）将患者分为四分位数。在这些四分位数中观察到DR患病率呈上升趋势。随后，采用逻辑回归分析来调整潜在的混杂因素，如性别、年龄、体重指数和糖尿病病程，并评估与这些四分位数相关的比值比（OR）。DR患病率随血清磷酸盐水平升高呈上升趋势。逻辑回归进一步证实血清磷酸盐水平仍然是DR的独立危险因素。
住院T2DM患者血清磷酸盐水平升高与DR患病率密切相关。需要进一步研究以确定因果关系。本试验已在chiCTR2000032374注册。
