Boyle J T, Tuchman D N, Altschuler S M, Nixon T E, Pack A I, Cohen S
Am Rev Respir Dis. 1985 May;131(5):S16-20. doi: 10.1164/arrd.1985.131.S5.S16.
The mechanism for the association between gastroesophageal reflux and bronchospasm is probably multifactorial. Our data support the view that microaspiration into the trachea may be an important mechanism for bronchospasm induced by gastroesophageal reflux and needs to be distinguished from simple reflux into the esophagus. Intraesophageal acidification alone quantitatively produces a much smaller airway response than does intratracheal acidification. A challenge test should be developed to correlate airway response following intraesophageal acidification to airway hyperactivity. We believe that the relationship of the diaphragm to the antireflux barrier deserves further study.
胃食管反流与支气管痉挛之间关联的机制可能是多因素的。我们的数据支持这样一种观点，即微量误吸至气管可能是胃食管反流诱发支气管痉挛的一个重要机制，且需要与单纯的食管反流相区分。单纯食管内酸化所产生的气道反应在数量上比气管内酸化所产生的要小得多。应开展一项激发试验，以关联食管内酸化后的气道反应与气道高反应性。我们认为膈肌与抗反流屏障的关系值得进一步研究。
